Related Episodes for Psilocybin

In this clip, Dr. Griffiths talks about the effect of dose on psilocybin mystical experiences and ‘bad trips’.

“In Dr. Raison’s randomized, double-blind study published in JAMA in 2016, it was shown that a single session of whole-body hyperthermia (core body temperature was elevated to 38.5 C) produced a significant antidepressant effect in people with major depressive disorder compared to those who received a sham control.”

“In the segment featuring the conversation with Dr. Griffiths, he explains that adherence to this protocol, which involves close participant monitoring, a dose methodically determined to reduce the likelihood of a challenging experience while maximizing therapeutic effects, and the provision of a safe physical environment and interpersonal support, is crucial for participant safety.”

“In this clip from Dr. Rhonda Patrick's appearance on The Tim Ferriss Show, she describes the supplements her parents use and separates a simple nutritional baseline from choices tied to individual health needs.”

“Dr. Brooks's exact practice of waking 96 minutes before dawn comes from the Vedic concept of Brahma Muhurta rather than a tested clinical protocol. Creatine may provide modest cognitive benefits in some settings, although results in healthy adults are mixed.”

“In more than 2,000 adults ages 51 to 80, higher Sitting-Rising Test scores were associated with longer survival, making floor-transfer ability a useful marker of functional capacity. Floor time can include cross-legged sitting, kneeling, side-sitting, or sitting with the legs extended.”

“A growing body of scientific evidence suggests that there's a correlation between nutrition, exercise, sleep, and stress management and having longer telomeres. Identifying the mechanisms that drive these correlations has proven challenging, but a few candidates stand out, including improvements in immune function and metabolic health.”

In this clip, Dr. Patrick explains how intense exercise beneficially alters tryptophan and kynurenine metabolism in a way that may benefit depression.

“Metformin, a drug commonly used to treat type 2 diabetes, has garnered interest as a longevity compound because it was shown to extend lifespan in some animal models. These effects are variable and seem to depend on the age and gender of the animals, as well as the dose provided.”

“The fact that poor sleep is linked with the aggregation of amyloid-beta plaques in the brain and Alzheimer's disease is not surprising. Although some strategies for improving the quality of sleep among people with Alzheimer's have been identified, this might be too late to turn the tide of cognitive decline.”