Related Episodes for APOE4 gene and associated risk for Alzheimer's disease | Dale Bredesen

“Evidence continues to emerge that illustrates that the fasting-mimicking diet, particularly its ability to cause immune cell turnover, may provide beneficial effects in the treatment of auto-immune diseases such as multiple sclerosis.”

“When produced during exercise (especially high intensity workouts like cycling, which shifts metabolism toward glycolysis to more quickly meet the high energetic demands), lactate switches on more than 600 genes involved in muscle adaptation, stimulates mitochondrial biogenesis – the process of making new mitochondria – and promotes protein synthesis, which is essential for muscle growth.”

“For people seeking better-supported ways to improve inflammatory health, she points to regular exercise, marine omega-3 intake, and sulforaphane-rich foods as practical areas with a larger human evidence base.”

“Dr. Rhonda Patrick talks at SF Nerd Nite about transgenerational effects of caloric restriction on longevity, B-vitamins silencing bad genes, cognitive stimulation reversing neurodegenerative disease, exercise increases neurogenesis, and ways in which vitamin D might influence aging.”

“A later crossover study using a lower weight-based dose found its clearest benefit in reasoning, while several memory, accuracy, fatigue, and sleepiness outcomes did not reliably improve. Routine muscle supplementation and acute sleep-loss research use different protocols.”

“Time-restricted eating can help some people reduce eating opportunities, although a 12-month trial found no additional weight or body-fat benefit when an eight-hour eating window was added to calorie restriction. Sleep also affects appetite and fat distribution.”

“Visceral fat can respond to changes in energy balance and physical activity. A meta-analysis of 40 randomized trials and 2,190 adults with overweight or obesity found that both exercise and calorie restriction reduced CT- or MRI-measured visceral fat.”

“This is a proposed metabolic advantage, not proof of slower brain aging. Small TBI trials found that sodium lactate lowered intracranial pressure more than mannitol in severe TBI and improved cognitive scores more than 3% sodium chloride in mild TBI.”

“In a randomized crossover study of 18 young men with overweight or obesity, ten three-minute walking or squat breaks spaced every 45 minutes across 8.5 hours lowered post-meal glucose exposure more than uninterrupted sitting or one continuous 30-minute walk.”

“Smaller crossover studies support the same practical direction. Sprint intervals improved the late insulin response after one four-hour night of sleep, and a two-week HIIT program attenuated the rise in glucose, insulin, and free fatty acids after 24 hours without sleep.”