Ranked by shared topics, with one result from each original episode.
“Although alcohol may help us feel calm and ready to sleep, it has surprising effects on REM sleep and maybe our waking behaviors too. In this Aliquot, Dr. Matthew Walker, Tim Ferriss, and I discuss some of the risks and surprising effects of alcohol on human health and behavior.”
“Roughly one-quarter of people living in the US carry a genetic variant of the apolipoprotein E gene, called APOE4, the most important genetic risk factor for Alzheimer's disease. Many lifestyle behaviors can mitigate risk, especially sleep hygiene, which provides an opportunity to rid the brain of toxic metabolic byproducts that can contribute to Alzheimer's disease risk.”
“Choline is particularly important during pregnancy and breastfeeding, but some evidence suggests that choline supplementation could carry some risks. In this Aliquot, I talk about the science surrounding choline.”
“Migraine is a neurological disorder that typically manifests as an intense, debilitating headache and is often accompanied by nausea, vomiting, and light sensitivity. Roughly 15 percent of people worldwide experience migraines, with women reporting them more often than men.”
“Vascular dysfunction, the loss of normal endothelial tone and permeability of blood vessels, is a common feature of most forms of dementia, including Alzheimer's disease. People who carry the APOE4 gene are at greater risk for vascular dysfunction and Alzheimer's disease.”
“Preventing dementia requires a lifelong and multipronged approach that involves keeping inflammation (and its aging effects) at bay and making healthy lifestyle choices, such as exercising and consuming omega-3 fatty acids.”
“Genetic predisposition, altered glucose uptake in the brain, high blood pressure, and other factors can weaken the barrier's integrity, allowing endotoxins and inflammatory immune cells to infiltrate the brain and increasing a person's risk for dementia.”
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“A four-week pilot study in people with type 2 diabetes reported improved insulin-stimulated glucose disposal after oral alpha-lipoic acid, while a three-week randomized trial found that intravenous 600 milligrams per day reduced diabetic neuropathy symptoms.”
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“Animal studies indicate that omega-3 deficiency may also reduce GLUT1 transporters in the brain. Other studies suggest that omega-3 supplementation reduces VCAM1 levels – a protein elevated with normal aging, which could be related to the breakdown of the blood-brain barrier.”
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“Approximately 25 percent of people living in the United States carry a genetic variant of this lipoprotein called APOE4, which is associated with higher circulating levels of LDL cholesterol and an increased risk for Alzheimer's disease.”