“It has attracted interest for its potential to activate mitophagy, the process cells use to clear out damaged mitochondria. In this Aliquot, I explain why mitochondrial cleanup matters for aging, why urolithin A production varies, and what early human studies suggest about its potential benefits.”
“And one potential strategy for mitigating our risk for Alzheimer's disease as we age is a "cognoscopy" – a battery of assessments that measures some of the key biomarkers associated with the disease and can inform the trajectory of treatment.”
“Poor sleep reduces the body's insulin sensitivity and changes a person's appetite, increasing the preference for high carbohydrate foods like pizza, pasta, and sweets. Lack of sleep also alters the gut microbiota and impairs immunity, putting us at risk for developing acute illnesses like colds and flu.”
“A growing body of evidence indicates that the fasting-mimicking diet may be beneficial in treating autoimmune disorders. In these Aliquot segments, Dr. Rhonda Patrick and Dr. Valter Longo describe the roles that diet and fasting play in maintaining or restoring proper immune function.”
“Zinc is an essential nutrient that participates in many biological processes and plays critical roles in immune function, protein synthesis, wound healing, DNA synthesis, cell division, and brain health.”
“Eating a typical Western diet – high in processed foods and sugar-sweetened beverages – raises blood glucose and insulin levels, promotes inflammation, and contributes to many neurological disorders, including Alzheimer's disease.”
“While infection with the SARS-CoV-2 virus shares symptoms with the common cold and influenza such as sore throat, cough, and runny nose, there are critical differences in the severity and duration of COVID-19 illness.”
“In this Aliquot, we share a variety of segments from different interviews covering some of the unconventional effects of omega-3 fatty acids and how to overcome some of the roadblocks to obtaining these effects.”
“The immune system has strategies for filtering these autoimmune cells out of circulation; however, this filter can malfunction due to age, genetic predisposition, disruption of the gut barrier and gut microbiota, or other environmental exposures.”
“Roughly one-quarter of people living in the US carry a genetic variant of the apolipoprotein E gene, called APOE4, the most important genetic risk factor for Alzheimer's disease. Many lifestyle behaviors can mitigate risk, especially sleep hygiene, which provides an opportunity to rid the brain of toxic metabolic byproducts that can contribute to Alzheimer's disease risk.”