Related Episodes for Combining intermittent fasting with a ketogenic diet | Dominic D'Agostino

“In a randomized crossover study of 18 young men with overweight or obesity, ten 3-minute walking or squat breaks spaced across 8.5 hours lowered post-meal glucose exposure more than uninterrupted sitting or one continuous 30-minute walk.”

“In more than 25,000 adults who reported no leisure-time exercise, a median of three one- or two-minute bouts per day was associated with 38 to 40 percent lower all-cause and cancer mortality and 48 to 49 percent lower cardiovascular mortality compared with no VILPA.”

“In this clip from Dr. Rhonda Patrick's appearance on The Diary of a CEO, she explains that a shorter eating window can make calorie reduction easier, while a longer overnight fast shifts fuel use toward fatty acids and ketones.”

“Mouse studies of feeding during infection also found different responses across bacterial and viral models, so a minimally processed dietary pattern, regular exercise, and normal hydration and nutrition during illness provide a more useful foundation than one universal food or fasting rule.”

“In eight young men, seven days of 1,000 milligrams of NR per day changed selected muscle NAD metabolites but did not alter substrate use, mitochondrial respiration, or signaling involved in adaptation to one hour of endurance exercise.”

“The study she cites did not test a dessert, sugary drink, or habitual added-sugar intake: 74 men completed a standard 75-gram oral glucose tolerance test, after which mean testosterone fell about 25% and remained below baseline at two hours.”

“In this Institute for Functional Medicine excerpt, Dr. Rhonda Patrick says about half of U.S. adults do not meet adequate magnesium intake and gives an average adult RDA near 400 milligrams per day, with sex-specific variation.”

“A 2025 network meta-analysis of 217 randomized trials and 15,684 people with knee osteoarthritis found that aerobic exercise was likely the most beneficial exercise category for pain, function, gait, and quality of life.”

“Other observational research in women has associated healthier dietary patterns with modestly lower acceleration on PhenoAge and GrimAge, while large prospective studies associate greater fruit and vegetable intake with lower cardiovascular and all-cause mortality.”

“There's a lot of exciting research right now into aging and maximum lifespan, but scientists have really just scratched the surface of the fascinating topic of how to live longer, healthier lives. Relevant Publications Rootzén, Holger, and Dmitrii Zholud.”