Related Episodes for "Hacking Your Genes" at SF Nerd Nite

“In this excerpt from Dr. Rhonda Patrick's A4M LongevityFest 2023 keynote, she argues that vigorous exercise is one of the most powerful tools for healthy aging because it can raise cardiorespiratory fitness.”

“Controlled human studies support acute brain-related responses to high-intensity exercise. Six short all-out cycling intervals improved selected learning and executive measures while increasing circulating BDNF, IGF-1, and VEGF; lactate tracked several of these changes.”

“Studies of centenarians suggest that lower levels of inflammation are associated with longevity. Different types of fiber provide fuel to diverse species of bacteria in the gut, which then synthesize byproducts that regulate the inflammatory process.”

“Dr. Patrick explains some of the early evidence that suggests the value prolonged fasting (48+ hours) may have from the standpoint of tissue rejuvenation and healthspan maintenance, as well as relevance for other more specific conditions.”

“In this clip, Dr. Valter Longo discusses the origin of the fasting-mimicking diet and a possible future which may lean away from a drug-centered mentality to one which allows the body to heal itself.”

“When produced during exercise (especially high intensity workouts like cycling, which shifts metabolism toward glycolysis to more quickly meet the high energetic demands), lactate switches on more than 600 genes involved in muscle adaptation, stimulates mitochondrial biogenesis – the process of making new mitochondria – and promotes protein synthesis, which is essential for muscle growth.”

“How too much iron can lead to protein aggregation and how vitamin D can prevent it. A program, directed by Gordon, called the Caenorhabditis Intervention Testing Program which tests potential longevity compounds that may extend the lifespan of several different species of worms.”

“Earlier long-term research in older male physicians found no cognitive benefit, and the main COSMOS trial did not significantly reduce invasive cancer, cardiovascular events, or mortality over a median of 3.6 years.”

“In a randomized crossover study of 18 young men with overweight or obesity, ten three-minute walking or squat breaks spread across 8.5 hours reduced post-meal glucose exposure more than uninterrupted sitting or one continuous 30-minute walk.”

“Exposure to bright light also promotes the release of cortisol, and, in turn, the hormone drives wakefulness during the daytime hours. Chronic stress and mis-timed exposure to light can dysregulate cortisol release and promote aging, however.”