Related Episodes for IGF-1 and its role in diabetes and Alzheimer's | Peter Attia

“Advanced glycation end-products, or AGEs for short, are created when the sugars, amino acids, and fats in food encounter heat. AGEs also form in the body during normal glucose metabolism. However, if high levels of AGEs accumulate in the tissues and blood, they can become pathogenic.”

“Sulforaphane switches on mechanisms that protect against cancer and other environmental insults. Sulforaphane is produced when the plants' cells are damaged by chewin or chopping and some culinary "hacks" favor its production.”

“Preventing dementia requires a lifelong and multipronged approach that involves keeping inflammation (and its aging effects) at bay and making healthy lifestyle choices, such as exercising and consuming omega-3 fatty acids.”

“As research progresses, my dietary and supplement habits adapt. At times, it's the ineffable quality of consciousness, submerged in a mental calculus of cost-benefits, that nudges a change of heart. Other times, it's the stark contradiction of new data that compels a shift.”

“Time-restricted eating involves consuming meals within a specific daily time window. However, choosing the optimal time frame for that window is influenced by many factors, the most important of which is circadian rhythmicity, which alters our body's metabolic responses to food.”

“A four-week pilot study in people with type 2 diabetes reported improved insulin-stimulated glucose disposal after oral alpha-lipoic acid, while a three-week randomized trial found that intravenous 600 milligrams per day reduced diabetic neuropathy symptoms.”

“Consensus evidence supports ApoB as a causal risk factor, but Dr. Attia’s proposed 10–30 mg/dL physiological range and treatment targets are attributed opinions, not universal guideline targets. Diet can change ApoB through several pathways.”

“Dr. Krauss explains how some people might be inappropriately prescribed statins while other people should be taking statins. In addition, his current research is investigating whether statins can increase the risk of diabetes, especially for women.”

“- Arthur Brooks, Ph.D. The episode closes with a framework from Brooks's work on the second half of life: jump, serve, worship, and connect, a framework he outlines in one of his earlier books, From Strength to Strength: "Jump" means proactively building the next thing, especially during liminal periods or unwelcome change, which Brooks sees as fertile ground for creativity.”

“Microbial responses to individual components of a person's diet may influence host health. Food ingredients, such as artificial sweeteners and dietary emulsifiers, are typically thought to be inert, however, recent evidence suggests they impact gut microbes, ultimately influencing human health.”