Related Episodes for Joe Rogan Experience #1178 - Dr. Rhonda Patrick

“Circulating LPS can also bind to lipoproteins, facilitating their absorption in the liver during LDL recycling, effectively removing LPS from circulation and lowering systemic inflammation – a phenomenon demonstrated mechanistically with statins that increase lipoprotein recycling by increasing LDL receptors.”

“1 02:37:05 - Mothers that chew xylitol gum starting mid-pregnancy and continuing until 6-12 months after birth lowered the oral streptococcus mutan bacteria, which is an anaerobic bacteria that plays a significant role in tooth decay, in their toddlers/children.”

“Some of the factors contributing to these variable phenotypes include persistent damage to our DNA and mitochondrial dysfunction, driven by an altered NAD:NADH ratio, the latter of which has recently been shown to be improved by certain dietary supplements like nicotinamide riboside.”

“A higher omega-3-index quintile was associated with lower all-cause mortality risk, but the estimated years of life were model-derived comparisons between quintiles, not observed gains from raising an index from 4% to 8%.”

In this clip, Drs. Levine and Patrick discuss lifestyle factors that accelerate epigenetic aging including smoking cigarettes or having a low omega-3 index.

“In this brief episode, we learn how restoring our dietary and sleep pattern to one that more closely syncs with those imposed by nature, especially by avoiding eating within 2-3 hours before bed and onset of melatonin production, may improve our health and potentially prolong our healthspan.”

“The good news is that extending sleep by ~1 hour per night has been shown to improve insulin sensitivity, normalize levels of appetite-regulating hormones, reduce cravings for sweet and salty foods, decrease sugar consumption, lower caloric intake, and aid in weight loss.”

“While Dr. Rhonda Patrick’s first video focused primarily on the micronutrients found in the various fruits and vegetables she put in her smoothie, this one, in addition to offering some modest changes on the recipe, instead focuses on the beneficial “hormetic” compounds that are NOT micronutrients.”

“In a small immobilization trial, five grams per day of omega-3 fatty acids reduced the loss of muscle volume in young women compared with sunflower oil, supporting continued research on omega-3s and disuse atrophy. Heat is the fourth proposed tool.”

“People who have narcolepsy, a chronic neurological disorder, experience very irregular sleep-wake cycles and may fall asleep during routine daily activities such as driving or troubleshooting a difficult problem.”