Related Episodes for How to Improve Metabolic Health with HIIT, Circadian-Timed Eating, & Sleep

“In addition, exercise preferentially causes the brain to take up lactate. Dr. Attia discusses some interesting research from several decades ago that uncovered the shifts in metabolism that occur in the human body and brain upon extreme fasting.”

“I am simply saying you would be even more healthy if you also included fiber...if you also included fruits and vegetables.” - Layne Norton, Ph.D. The Carnivore Diet Eating an all meat or all animal product diet—commonly referred to as the carnivore diet—has been hailed by many as the only diet that’s provided a cure for their autoimmune disease or other health issues.”

“Whether metformin reduces the risk of cancer in healthy people remains to be seen. In this clip, Dr. Rhonda Patrick describes the relationship between metformin and cancer incidence and the relevance for those with type 2 diabetes.”

“A meta-analysis of resistance-training trials found that protein supplementation produced modest additional gains in strength and fat-free mass, with average fat-free-mass benefit plateauing near 1.62 g/kg/day. This is a group estimate, not a precise requirement for every older adult.”

“In turn, cellular levels of nicotinamide adenine dinucleotide, or NAD+, a coenzyme that participates in the production of cellular energy, rise, switching on energy-generating pathways and activating enzymes such as sirtuins.”

“It remains unknown whether these levels are sufficient for optimal immunological functioning. A large meta-analysis of 32 studies, spanning nearly 50 years, suggests that 25-hydroxyvitamin D levels below 30 ng/mL are associated with a higher risk of death from all causes.”

“Dr. Patrick also discusses STEP 5, in which two years of treatment produced about 15.2 percent loss versus 2.6 percent with placebo, with the curve leveling while participants remained on treatment. Dual GIP/GLP-1 therapy can produce still larger losses in some trials.”

“One hypothesis is that DNA repair enzymes, known as PARP (poly ADP-ribose polymerase), might be using up more NAD+ to fix the accumulated DNA damage that occurs with age. Alternately, the cellular pathway that recycles NAD+ may decline in performance with age.”

“Chiefly, sleep deprivation triggers the onset of a "loneliness phenotype" by inducing critical changes within the brain that alter behavior and emotions, disturb metabolic processes, and influence the expression of immune-related genes.”

“When most people think about certain lifestyle factors that affect insulin sensitivity and blood glucose levels, they think about macronutrient composition, or calories, or fasting, or exercise (and lack of), but they don’t often think about sleep.”