Replenishing falling levels of NAD+ may be a strategy for reducing some symptoms of aging | Eric Verdin

Parent Episode: Dr. Eric Verdin on Ketogenic Diet Longevity, Beta-Hydroxybutyrate, HDAC Inhibitors & NAD+

Nicotinamide adenine dinucleotide (NAD+) is a coenzyme required for mitochondria to produce energy. NAD+ levels are one way for energy to be circulated within the cell, and levels rise while fasting and decrease during aging. A group of enzymes called sirtuins rely on NAD+ to exert their beneficial activities, functioning less well as levels decline. Other NAD+ dependent enzymes also function less efficiently with aging. NAD+ supplementation is a preliminary approach to replenish the NAD+ levels lost to aging. The reason NAD+ levels decline with aging is currently unknown. One hypothesis is that DNA repair enzymes, known as PARP (poly ADP-ribose polymerase), might be using up more NAD+ to fix the accumulated DNA damage that occurs with age. Alternately, the cellular pathway that recycles NAD+ may decline in performance with age. In this clip, Dr. Eric Verdin explains how nicotinamide adenine dinucleotide levels diminish with age and describes the ongoing research to understand the reasons why.

Member support keeps us strong.

If you enjoy the fruits of foundmyfitness, you can participate in helping us to keep improving it. Creating a pay-what-you-can subscription does just that! Plus, we throw in occasional member perks and, more importantly, churn out the best possible content without concerning ourselves with the wishes of any dark overlords.

Our website is 100% supported by people like you through this pay-what-you-can mechanism.

Monthly Support

  • Fundamentals

    $15 / month
  • Loyal Fan

    $25 / month
  • Super Fan

    $50 / month
  • Power Supporter

    $125 / month
  • Heroic Supporter

    $250 / month

One-time Support

You can also become a one-time supporter with a single donation in any amount.