Related Episodes for Mitophagy: a signal for mitochondrial biogenesis, metabolic adaptation, and cellular differentiation

“When produced during exercise (especially high intensity workouts like cycling, which shifts metabolism toward glycolysis to more quickly meet the high energetic demands), lactate switches on more than 600 genes involved in muscle adaptation, stimulates mitochondrial biogenesis – the process of making new mitochondria – and promotes protein synthesis, which is essential for muscle growth.”

“Unlike antibody treatments that target the PCSK9 protein (an important regulator of blood cholesterol levels), which are very expensive, base editing could deliver permanent protection from hypercholesterolemia with just one dose.”

“Dr. Patrick discusses paraquat and rotenone because both can damage mitochondria and are used experimentally to model Parkinson-like neurodegeneration, but that rationale does not prove that either chemical caused disease in this population.”

“In this clip from Dr. Rhonda Patrick's appearance on The Mel Robbins Podcast, she outlines a practical sleep audit built around adequate sleep, morning light, regular timing, earlier meals, and alcohol awareness.”

“In this member Q&A clip, Dr. Rhonda Patrick shares four practices she uses or finds compelling for healthy aging: sauna, sulforaphane-rich foods or supplements, time-restricted eating, and high-intensity interval training.”

“In a randomized crossover study of 18 young men with overweight or obesity, ten three-minute walking or squat breaks spread across 8.5 hours reduced post-meal glucose exposure more than uninterrupted sitting or one continuous 30-minute walk.”

“In a UK Biobank study of 25,241 adults who reported no leisure-time exercise, about three daily bouts lasting one or two minutes were associated with 38 to 40 percent lower all-cause and cancer mortality and 48 to 49 percent lower cardiovascular mortality compared with no VILPA.”

“A systematic review found no overall improvement in mood after cold-water immersion, while a small randomized trial found that repeated whole-body cryotherapy improved depression scores when added to standard pharmacological treatment.”

“A single 0.35-gram-per-kilogram dose of creatine monohydrate, equal to 24.5 grams for a 70-kilogram adult, reduced fatigue and improved word memory and processing speed on selected tasks versus placebo. It also changed brain-energy measures.”

“The heart becomes smaller and less compliant with sedentary aging, which can limit how effectively it fills during exercise. In this clip from Dr. Rhonda Patrick's appearance on PBD Podcast, she describes a two-year randomized trial in healthy but sedentary adults ages 45 to 64.”