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Related Episodes for How NAD+ resets the circadian clock and regulates sirtuins | David Sinclair

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Aliquot #143: How to Reduce the Strain of Shift Work

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“Shift work creates a chronic disruption of circadian rhythms that affects sleep, metabolism, decision-making, and long-term health, often in ways people don't recognize until years later. In this Aliquot, joined by Drs.”

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Duration: 33m 50s
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Aliquot #146: When Is the Best Time to Exercise?

Jun 11, 2026

“In this Aliquot, Drs. Satchin Panda, Andrew Huberman, Layne Norton, Brad Schoenfeld, Martin Gibala, and I examine how circadian biology, training intensity, and life schedule shape exercise timing. We also explore what that means for deciding when to train.”

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Aliquot #149: The Biology of a Better Mood

Jul 31, 2026

“Physical activity, sleep, light exposure, heat, and certain nutrients may all affect systems involved in mood regulation, including inflammation, circadian rhythms, neuroplasticity, and brain energy metabolism. In this Aliquot, Drs.”

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Aliquot #17: Time restricted eating for better metabolic health, part 2

Jan 11, 2021

“Coordination of meal timing with the circadian rhythm can reduce markers of inflammation and affect aspects of metabolic health, including glucose regulation and insulin sensitivity. Animal studies suggest that overnight fasting induces autophagy.”

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Duration: 22m 7s
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Aliquot #20: Fasting and athletic performance

Feb 15, 2021

“The timing of eating and exercise, especially in elite athletes, hasn't been studied and may, in fact, require self-experimentation by the athletes to identify the perfect interval of fasting to support their optimal performance.”

aliquot exercise metabolism performance
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Aliquot #25: Coffee, caffeine, and sleep

Mar 29, 2021

“Coffee consumption is associated with protection from several chronic diseases. Coffee's beneficial effects may stem from its ability to induce autophagy; however, other evidence points to the benefits of caffeine, which can reset the body's internal clocks in the morning.”

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Aliquot #35: Sauna use mimics the physiological effects of exercise

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“As a result, sauna use is associated with lower risk of cardiovascular and neurodegenerative diseases. The mechanisms that drive these effects are likely due to increased heat shock proteins and metabolic and hormonal changes that accompany exercise and sauna use.”

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Aliquot #47: Aligning food intake with the body's circadian rhythms

Dec 21, 2021

“Circadian rhythms play key roles in metabolic health and ultimately influence body weight, performance, and susceptibility to diseases like diabetes and cancer. Aligning food intake with circadian rhythms can improve many aspects of metabolic health.”

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Aliquot #5: Light exposure: Striking a balance for sleep and mental health

Sep 29, 2020

“Regulating the amount of light in our environment is crucial for a good night's sleep and a good mood the next day. Habits such as using blue light-emitting electronics close to bedtime can reduce melatonin production by as much as 20 percent, impairing sleep.”

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Aliquot #61: How dietary fiber influences metabolic health

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“Dietary fiber is a broad term that refers to the non-digestible components of fruits and vegetables. Gut microbes break down certain types of fiber, releasing micronutrients trapped in the fiber matrix and producing beneficial metabolic byproducts, such as short-chain fatty acids.”

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