Ranked by shared topics, with one result from each original episode.
“Cognitive enhancement is a hot topic, but the best ways to sharpen focus, boost motivation, and support brain health aren't always clear-cut. Stimulants like nicotine and caffeine offer immediate benefits but come with trade-offs—some minor, others riskier.”
“From THC, CBD, alcohol, caffeine, and nicotine to melatonin, magnesium, glycine, and calming botanicals, these compounds can either support restorative sleep or subtly hijack it, changing REM, deep sleep, and circadian timing in ways we often do not feel until the next day.”
“In this Aliquot, sleep scientist Dr. Michael Grandner explains why sleep apnea is so often missed, how these nightly breathing disturbances affect the body, and which treatments can meaningfully improve sleep and long-term health.”
“The different stages of sleep provide crucial periods during which the body recalibrates to promote both mental and physical well-being. In this clip, Dr. Matthew Walker describes how the different stages of sleep influence emotional and cardiovascular health.”
“These changes increase infection risk, weaken vaccine responses, and reduce early cancer surveillance. Yet immune aging is not fixed. Movement, sleep, stress regulation, temperature exposure, and nutrition shape immune cell balance and inflammatory activity over time.”
“In this Aliquot, I walk through how that plays out in humans, where the strongest evidence shows up, and where it doesn't, with NAD researcher Dr. Charles Brenner—and why I'm taking it now after being skeptical.”
“A more useful approach is to focus on what you can do to reduce its effects. In this Aliquot, Dr. Kelly Starrett explains why standing more is not enough, how to build movement into your workday, and why it matters for long-term mobility.”
“The timing of eating and exercise, especially in elite athletes, hasn't been studied and may, in fact, require self-experimentation by the athletes to identify the perfect interval of fasting to support their optimal performance.”
“Poor sleep reduces the body's insulin sensitivity and changes a person's appetite, increasing the preference for high carbohydrate foods like pizza, pasta, and sweets. Lack of sleep also alters the gut microbiota and impairs immunity, putting us at risk for developing acute illnesses like colds and flu.”
“The decline of deep sleep begins early in life, nearly disappears by age 80, increasing the risk for Alzheimer's disease. These Aliquot segments feature Dr. Charles Raison, a professor of psychiatry, and Dr. Matthew Walker, a professor of neuroscience and psychology.”