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Related Episodes for The link between sirtuins, calorie restriction, fasting, and the insulin pathway | David Sinclair

Ranked by shared topics, with one result from each original episode.

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What the Omega-3 Index May Reveal About Longevity

Dec 23, 2025

“In this clip from Dr. Rhonda Patrick's presentation at the Vibrant Wellness Longevity Summit, she explains how the Omega-3 Index measures EPA and DHA in red-blood-cell membranes as a longer-term marker of omega-3 status.”

nutrition aging heart disease omega-3
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Which Supplements Matter Most After Age 65?

Feb 3, 2026

“Lutein and zeaxanthin also have evidence in age-related eye disease, although the AREDS2 trial did not find an additional reduction in progression to advanced macular degeneration in its primary comparison. Magnesium and creatine address different needs.”

vitamin d aging omega-3 melatonin
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163
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Why Protein and Resistance Training Protect Muscle Across Life

Apr 16, 2024

“A meta-analysis of 49 resistance-training studies found small additional gains from protein supplementation, with fat-free-mass gains leveling near 1.6 grams per kilogram per day in the studied populations.”

protein nutrition exercise aging
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164
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Aerobic exercise alters tryptophan and kynurenine metabolism (beneficial for depression)

Apr 9, 2022

In this clip, Dr. Patrick explains how intense exercise beneficially alters tryptophan and kynurenine metabolism in a way that may benefit depression.

depression exercise metabolism aerobic
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165
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Aliquot #17: Time restricted eating for better metabolic health, part 2

Jan 11, 2021

“Coordination of meal timing with the circadian rhythm can reduce markers of inflammation and affect aspects of metabolic health, including glucose regulation and insulin sensitivity. Animal studies suggest that overnight fasting induces autophagy.”

aliquot metabolism insulin resistance fasting
Duration: 22m 7s
166
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Aliquot #20: Fasting and athletic performance

Feb 15, 2021

“The timing of eating and exercise, especially in elite athletes, hasn't been studied and may, in fact, require self-experimentation by the athletes to identify the perfect interval of fasting to support their optimal performance.”

aliquot exercise metabolism performance
Duration: 28m 28s
167
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Aliquot #35: Sauna use mimics the physiological effects of exercise

Jul 26, 2021

“As a result, sauna use is associated with lower risk of cardiovascular and neurodegenerative diseases. The mechanisms that drive these effects are likely due to increased heat shock proteins and metabolic and hormonal changes that accompany exercise and sauna use.”

aliquot exercise metabolism heat stress
Duration: 21m 57s
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Aliquot #47: Aligning food intake with the body's circadian rhythms

Dec 21, 2021

“Circadian rhythms play key roles in metabolic health and ultimately influence body weight, performance, and susceptibility to diseases like diabetes and cancer. Aligning food intake with circadian rhythms can improve many aspects of metabolic health.”

aliquot cancer metabolism diabetes
Duration: 28m 16s
169
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Aliquot #61: How dietary fiber influences metabolic health

Jul 5, 2022

“Dietary fiber is a broad term that refers to the non-digestible components of fruits and vegetables. Gut microbes break down certain types of fiber, releasing micronutrients trapped in the fiber matrix and producing beneficial metabolic byproducts, such as short-chain fatty acids.”

aliquot gut microbiome metabolism
Duration: 29m 2s
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Aliquot #63: Personalizing diet with a continuous glucose monitor

Jul 27, 2022

“Continuous glucose monitors – CGMs, for short – are wearable devices that measure blood glucose levels through a tiny sensor placed under the skin. The CGM communicates with your smartphone and provides nearly real-time information about your blood glucose levels.”

aliquot diet metabolism biomarkers
Duration: 46m 1s
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