Related Episodes for The Overlooked Blood Markers of Metabolic Aging

“Other hormetic responses to cold exposure include increased production of PGC1-alpha, a protein that promotes mitochondrial biogenesis, the production of new, healthy mitochondria, and the activation of brown fat – a phenomenon once thought to occur only in newborns, but now known to occur in adults, especially after cold exposure.”

“The most compelling human signal appears when the brain is under acute strain. In a randomized crossover study, a single dose of 0.35 grams per kilogram during 21 hours of sleep deprivation changed cerebral energy metabolites and preserved selected measures of cognitive performance.”

“Healthy, well-nourished adults can usually synthesize enough, and athlete trials have not found consistent improvements in immune measures, aerobic performance, body composition, or intestinal permeability from routine supplementation.”

“A critical element in healthiness is the timing and content of our meals. Time-restricted eating, a form of daily fasting wherein the time of the day during which a person eats is limited, capitalizes on the body's natural circadian metabolic rhythms to promote health.”

“Moreover, taking mega doses (i.e. 400 IU/day) of alpha tocopherol has the unintended side-effect of actually depleting tissue levels of another important form of vitamin E that plays an anti-inflammatory role, known as gamma tocopherol.”

“Dom's efforts at teasing out the differences between induced nutritional ketosis (through a low carbohydrate, high fat diet) and ketosis from the dietary introduction of exogenous ketones, like beta-hydroxybutyrate, especially in the context of therapeutic and performance enhancing effects.”

“Her practical message is to reduce the frequency and size of large glucose exposures. Foods with intact fiber, protein, and minimally processed carbohydrates digest more slowly than refined added sugar, while regular exercise gives skeletal muscle a large destination for circulating glucose.”

“While some forms of Parkinson's disease are genetic, most cases involve a complex interaction between genetic and environmental risk factors. In the early 1980s, intravenous drug users inadvertently injected a contaminated drug and developed parkinsonian symptoms overnight.”

“In a two-year trial of 237 postmenopausal women, approximately 9 to 10 grams per day combined with resistance training and walking did not add a bone-density benefit, so its role is better framed around muscle and physical function.”

“Patients assigned to supervised exercise during neoadjuvant chemoradiation, followed by continued activity before surgery, were more likely to achieve a complete or near-complete pathological response than those receiving usual care.”