What FoundMyFitness Has Covered
PremiumIron is essential but must be tightly regulated: the brain uses transferrin-mediated transport to support enzyme function while limiting excessive oxidative damage, and excess iron has been linked to protein aggregation and the distinctive challenges of…
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Based on available source text from 9 of the first 10 results.
Aliquot #137: How to Optimize Iron without Causing Overload
“In this Aliquot, I'll explore how to recognize and address iron deficiency, the unique challenges of iron overload in aging, the ways alcohol may influence brain iron, and how infants tightly regulate iron as a built-in defense against infection.”
Episode
Gordon Lithgow, Ph.D. on Protein Aggregation, Iron Overload & the Search for Longevity Compounds
“How heat stress activates genetic pathways, including heat shock proteins, in worms and humans that lower protein aggregation and extend lifespan in worms. How too much iron can lead to protein aggregation and how vitamin D can prevent it.”
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Iron levels in breast milk are low (what this means for breast feeding longer than 6 months) | Biology of Breast Milk
“Some nutrients in breastmilk are low, regardless of maternal status. Iron, in particular, is lacking, a seemingly counterintuitive biological phenomenon that is crucial to reduce the risk of life-threatening infections in the newborn.”
Breast milk and breastfeeding
“By the age of six months, however, iron deficiency anemia may manifest, so introducing iron-rich complementary foods is recommended. In addition, breast milk contains negligible amounts of vitamin D and is typically considered inadequate to prevent vitamin D deficiency in exclusively breastfed infants.”
Blood-brain barrier
“The body tightly controls the movement of iron in the brain to maximize enzyme efficiency without causing excessive oxidative damage. Iron is shuttled through the bloodstream by the protein transferrin.”
Zinc
“A single-meal study demonstrated that iron given as an aqueous solution of doses up to 5.585 milligrams per deciliter reduced zinc absorption in a dose-dependent manner. When iron was supplemented with the amino acid histidine or added to solid food, zinc absorption was minimally affected.”
Vitamin C
“Multiple in vitro and in vivo studies suggest that high dose vitamin C can assist in cancer cell death primarily due to the formation of hydrogen peroxide. Some evidence suggests that vitamin C generates hydrogen peroxide by interacting with high levels of iron found in cancer cells.”
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Which Supplements Do Children Actually Need?
“Combining products requires checking total vitamin D, vitamin A, zinc, iodine, selenium, iron, and other overlapping ingredients. Protein powder can be a convenient food when an actual protein gap exists.”
Neu5Gc
“The critical connection between iron and the developing brain suggests that there might be an evolutionary reason why humans can tolerate the antigenic sugar Neu5Gc. More clinical research is needed to determine to which degree Neu5Gc might drive the development of cardiovascular disease and cancer – and how direct a role it plays.”
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