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“More than a century of research has demonstrated that nicotinamide adenine dinucleotide (NAD+) is an indispensable mediator of vital metabolic and physiological processes, including energy production, DNA synthesis and repair, and regulation of gene expression – across multiple species.”

“In this clip from Dr. Rhonda Patrick's appearance on Huberman Lab, she explains the evidence behind several supplements in her routine. In the COSMOS trial program, a standard daily multivitamin produced a small average benefit in global cognition and episodic memory among older adults over two to three years.”

“Unlike chemicals that are rapidly eliminated in urine, some long-chain PFAS undergo biliary excretion and intestinal reabsorption, contributing to biological half-lives measured in years and the nickname “forever chemicals.” PFAS exposure may increase the risk of cancer, liver damage, and immune system impairment.”

“But what does the science say? In this Aliquot, Dr. Jed Fahey and I discuss the pros and cons of eating meat as well as the confounding factors that may influence the risks associated with meat consumption.”

“A systematic review found that temperature, fat, acidity, contact time, and material composition can affect the migration of bisphenols and phthalates, supporting the use of glass or stainless steel for hot, oily, or acidic foods when practical.”

Dr. Rhonda Patrick discusses supplement timing, exercise timing, supplements in older adults, folic acid vs. folate, and hydrogen-rich water.

“Whereas the common form of Alzheimer's disease is characterized by memory loss and the inability to form new memories, one subtype of the disease is characterized by profound deficits in organizational skills, math capabilities, and visual perception.”

“Longer-term nutrient status offers another perspective: in a randomized trial of adults with overweight or obesity, 15 grams of psyllium daily for three months did not significantly alter serum micronutrient concentrations relative to control.”

“A recent randomized-control study showed that babies fed formula fortified with milk fat globule membranes and lactoferrin had accelerated neurodevelopment compared to babies fed normal formula. Breast milk also contains omega-3 fatty acids which are critical for brain development in infants.”

“But the effects of liquid sugar extend to longevity, as well. In fact, consumption of sugar-sweetened beverages is associated with dramatically accelerated telomere shortening – equivalent to as much as five years of a person's life.”