Search results for aging

“Learn more about autophagy in this topic article from FMF. This episode is decidedly focused on autophagy, an important cellular program that is inducible by dietary fasting and has broad implications for aging and cancer.”

“Whereas fasting turns off multiple pathways associated with aging, such as mTOR and IGF-1, eating for optimal fitness activates these important processes. The IGF-1 pathway, in particular, plays key roles in growth and is strongly associated with cancer.”

“New diagnostic tools, such as blood and cerebrospinal biomarkers and sensitive MRI techniques, can detect vascular problems in cognitively normal individuals, allowing for earlier intervention and treatment.”

“These two processes are in equilibrium during our younger years when exercise and food intake work in concert to maintain muscle mass. As we age, this equilibrium wanes, and an imbalance is created favoring breakdown, which contributes to sarcopenia – the loss of muscle mass and strength that accompanies aging.”

“While exercise and caloric restriction have the potential to slow aging, rejuvenation has the potential to repair the damages associated with aging once they have occurred. In this clip, Dr. Eric Verdin explains how exercise and nutrition form the cornerstone of strategies to slow aging, but exciting approaches lie ahead.”

“Maintaining muscle mass is essential for health, but muscle mass decreases markedly with aging, compromising overall fitness and contributing to frailty, disability, and falls. Animal models demonstrate that intermittent fasting is generally beneficial for maintaining muscle mass, but in some disease states, such as ALS, or Lou Gehrig's disease, it can be detrimental.”

“Although a variety of factors likely influence this difference in aging rates, telomere length stands out as a critical factor. Women have considerably longer telomeres than men – a difference manifested at birth and probably due to the influence of sex hormones.”

“Although we often have little control over the genetic and environmental factors, lifestyle is an easy target for influencing how we age. In this clip, Dr. Elissa Epel describes how even small lifestyle changes can have an effect on telomere length and healthy aging to compress morbidity.”

“Similar in molecular structure to insulin, IGF-1 (insulin-like growth factor 1) has been implicated in the aging process. Protein intake increases IGF-1 levels in humans, independent of total caloric consumption.”

“In the Dallas Bed Rest and Training Study, three weeks of strict bed rest at age 20 reduced the five participants' exercise capacity more than 30 years of aging, showing how strongly deconditioning can affect cardiorespiratory fitness.”