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“The most compelling human signal appears when the brain is under acute strain. In a randomized crossover study, a single dose of 0.35 grams per kilogram during 21 hours of sleep deprivation changed cerebral energy metabolites and preserved selected measures of cognitive performance.”

“In this clip, Dr. Dale Bredesen talks about strategies for identifying the factors that contribute to one's risk of developing Alzheimer's disease and describes strategies for mitigating that risk.”

“Sprint-interval exercise improved reaction time on selected executive-function tasks for about 10 to 30 minutes in a controlled study, supporting Dr. Patrick's practice of using a short workout before an early talk or demanding meeting.”

“Although whole-body hyperthermia and sauna use share some similarities, whole-body hyperthermia sessions are typically longer (an hour or more) and the participant's head is spared (often kept cool with ice or cool cloths), prolonging the participant's tolerance to the intense heat.”

“Physical activity, sleep, light exposure, heat, and certain nutrients may all affect systems involved in mood regulation, including inflammation, circadian rhythms, neuroplasticity, and brain energy metabolism. In this Aliquot, Drs.”

“Advanced glycation end-products, or AGEs for short, are created when the sugars, amino acids, and fats in food encounter heat. AGEs also form in the body during normal glucose metabolism. However, if high levels of AGEs accumulate in the tissues and blood, they can become pathogenic.”

“In this Aliquot, cardiologist Ben Levine, nutritional scientist and champion powerlifter Layne Norton, and I discuss the importance of recovery, how best to approach it, and some surprising, often overlooked aspects of this important part of fitness.”

“The benefits of HIIT include improvements in muscle tissue oxidative capacity, enhanced insulin response, improvements in heart function, and increased lactate – an important source of fuel for the heart, brain, and muscles.”

“Jet lag often shows up as fatigue after a long flight, reflecting a mismatch between your internal clock and the external world. In this Aliquot, joined by Drs. Michael Grandner and Darren Candow, I explain how jet lag works, which signals are most important for resetting your clock, and how to reduce jet lag before travel and recover more quickly after arrival.”

“As a result, sauna use is associated with lower risk of cardiovascular and neurodegenerative diseases. The mechanisms that drive these effects are likely due to increased heat shock proteins and metabolic and hormonal changes that accompany exercise and sauna use.”