Search results for blood-brain barrier

Dr. Rhonda Patrick, Dr. Darya Rose, and Kevin Rose discuss turmeric's ability to increase detoxification enzymes through hormesis.

“Dr. Patrick's practical answer is to use black coffee, a small amount of cream or MCT, or an unsweetened plant milk when frequent additions worsen the lipid tradeoff, and to assess ApoB rather than assume an additive is harmless.”

Dr. Rhonda Patrick explores melatonin's antioxidant properties, curcumin supplementation, antinutrients, and SARMs in her latest Q&A.

“One laboratory study found that disposable paper cups exposed to 85 to 90°C water released about 25,000 micron-sized particles into 100 milliliters within 15 minutes, along with many smaller particles. Tea bags can provide another source of exposure.”

“Skilled exercises — including tennis, yoga, and tai chi — involve goal-oriented movement in which accuracy is important to accomplish the desired outcome. Evidence from animal studies suggests that skilled exercise enhances blood flow to cognitive circuits, which is a marker of cerebrovascular function.”

“Aerobic and skilled exercise may exert their effects differently on the parkinsonian brain. Preclinical research indicates that animals performing skilled exercise have enhanced blood flow to cognitive circuits — suggesting diverse pathways may stimulate and contribute to reparative mechanisms.”

“While ketogenic diets may not be optimal for adding muscle mass, they may be suitable for preserving muscle mass and improving other metabolic parameters, particularly during weight loss and fasting.”

“Vigorous exercise also creates strong metabolic signals. Dr. Patrick describes lactate as both a fuel and a signaling molecule and explains how exercise intensity can increase catecholamine release and brain-derived neurotrophic factor.”

“A separate eight-week pilot gave 20 grams per day to 20 people with Alzheimer's disease, increased measured brain creatine by 11%, and observed improvements on several cognitive tests. This clip is excerpted, with permission, from Dr. Rhonda Patrick's appearance on The Peter Attia Drive.”

“Dr. Patrick had not completed an evidence review of glycine, GABA, or myo-inositol for sleep. She notes that oral GABA does not readily cross the blood-brain barrier and offers gut-vagus signaling only as a possible mechanism, not an established sleep effect.”