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“For example, an athlete on a strict diet may prefer twice a year, whereas an obese person may choose monthly. Some individuals favor this strategy for weight loss as it requires them to struggle for five days and then allows them to eat without restrictions for the remainder of the month.”

“The stability of DNA methylation patterns - in terms of sample reliability - makes the use of epigenetic clock data an attractive tool in the hands of researchers investigating aging around the world.”

“Hormesis is a compensatory defense response to a stressor that conditions the body against future stressors. Cold exposure, a powerful hormetic stressor, activates the body's cold shock response, the goals of which are simple: to reduce heat loss and increase heat production.”

“In this clip, Drs. Levine and Patrick discuss how genes that are important for embryonic development can tell us a lot about aging. Dr. Levine gives her insights into the process of aging - is it the accumulation of random damage or the malfunction of a cellular program?”

“A growing body of evidence indicates that the fasting-mimicking diet may be beneficial in treating autoimmune disorders. In these Aliquot segments, Dr. Rhonda Patrick and Dr. Valter Longo describe the roles that diet and fasting play in maintaining or restoring proper immune function.”

“Davidson reported that five minutes of daily Healthy Minds Program practice for 28 days produced a significant decrease in interleukin-6 (IL-6), a pro-inflammatory cytokine, measured three months after the formal intervention ended and compared with an untreated control group.”

“In a randomized trial of 120 older adults, a walking program that progressed to about 40 minutes three times per week increased anterior hippocampal volume by approximately 2 percent and improved spatial memory over one year.”

“Breaking the fast typically occurs early in the morning, coinciding with the human body's highest insulin response. Consequently, people who break their fast later, such as midday, might not get the same metabolic benefits associated with time-restricted eating as someone who breaks their faster earlier.”

“However, for individuals seeking health benefits without athlete-level commitments, even shorter, high-intensity sessions can lead to significant fitness improvements, emphasizing the importance of moving out of the low fitness range.”

“For example, if basic research reveals that a particular diet is best for longevity, yet no long-lived populations around the world eat this way, then one may choose to be cautious about this diet.”