Green tea compound and vitamin B3 derivative may restore the ability of aging brain cells to clear waste.
“Amyloid-beta protein levels decreased inside neurons. Normally present in the brain, this protein can accumulate and form toxic clumps in Alzheimer's disease, damaging brain cells. When recycling pathways (autophagy) were blocked, GTP increased.”
Episode
Joe Rogan Experience #1054 - Dr. Rhonda Patrick
“00:04:35 - DHA in phospholipid form passes into the brain more readily than DHA in triglyceride form. Study 1; Study 2. 00:06:00 - The phospholipid form of DHA may be beneficial for people with APOE-related Alzheimer’s disease.”
Long-term poor sleep predicts amyloid-beta deposition in the brain.
“Sleep disruption is linked with the pathophysiology of Alzheimer's disease, with characteristic changes in sleep emerging early in life, well before the clinical onset of the disease. A key player in the development of Alzheimer’s disease is amyloid-beta.”
Supplemental probiotics for 12 weeks improved cognition in Alzheimer's patients & also lowered inflammatory markers.
“Other studies have shown that gut bacteria are able to modulate the levels of GABA, norepinephrine, serotonin, dopamine, and acetylcholine through the gut-brain axis. I spoke with the gut experts, Drs.”
Common fungi may override the brain's defense system, impairing blood-brain permeability and driving amyloid plaque formation.
“It participates in various cellular functions, including forming and maintaining synapses, which are essential for communication between nerve cells. Abnormal APP processing can promote amyloid-beta accumulation, a hallmark of Alzheimer's disease.”
Insulin improves dopamine signaling in regions of the brain associated with eating behavior.
“Future research should include participants with insulin resistance to gain a better understanding of the effects of obesity and metabolic disease on the brain. Link to full publication. Learn more about the connection between insulin resistance and Alzheimer’s disease in this clip with Dr. Peter Attia from the FoundMyFitness Podcast.”
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