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"Interrupted" reprogramming with Yamanaka factors reverse epigenetic age | Steve Horvath

Dec 31, 2020

“When cells are exposed to Yamanaka factors for too long, Dr. Horvath explains, this loss of cellular identity may carry cancer risk. In support of this hypothetical approach, a study using a mouse model of premature aging showed that short-term expression of four of these factors ameliorated cellular and physiological hallmarks of aging and prolonged lifespan.”

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