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“In this video Dr. Rhonda Patrick interviews Dr. Bruce Ames about his triage theory, which he proposes that the body has developed a rationing response to shortages of micronutrients (vitamins and minerals) throughout evolution.”

Dr. Rhonda Patrick discusses xylitol safety, strategies to reduce hemoglobin A1C, klotho and dementia risk, and the timing of hormone replacement therapy.

“Diamandis and Robbins are a dynamic duo, having paired up with co-author Dr. Robert Hariri to write Life Force, a best-selling book that describes breakthroughs in precision medicine and health technologies that can help people live longer, healthier, more fulfilling lives – in the very near future.”

Dr. Rhonda Patrick answers audience questions on various health, nutrition, and science topics in this Q&A session.

“Many people may find the prolonged fast too onerous, but the fasting-mimicking diet, an approach that recapitulates many of the same effects of prolonged fasting with a hyper-low calorie, low protein, higher fat diet stretched out over a longer interval of five days, may offer a more palatable strategy for activating autophagy.”

“Modulating autophagy – through fasting and exercise (which both increase acetyl CoA) or intake of nutrients like spermidine – represents a promising therapeutic approach for extending human lifespan and healthspan.”

“In Dr. Raison’s randomized, double-blind study published in JAMA in 2016, it was shown that a single session of whole-body hyperthermia (core body temperature was elevated to 38.5 C) produced a significant antidepressant effect in people with major depressive disorder compared to those who received a sham control.”

“NSAIDs (e.g., Ibuprofen) Nonsteroidal anti-inflammatory drugs (NSAIDs) can reduce soreness and inflammation but may also impair muscle growth and adaptation if used chronically. Dr. Andy Galpin takes a "calculus" approach here: if you need it to train or perform—such as during an acute injury—it's likely okay in moderation.”

“01:37:30 - Everyone has different levels of vitamins & minerals in their body, but baseline for drugs is always the same: zero. This is an important fundamental difference. 01:42:20 - Years of research has to be published even if results aren't great, and this requires salesmanship.”

“To look for functional mitochondrial effects, Dr. Attia uses controlled Zone 2 work while sampling lactate, with output near 2 mmol/L. He says statins have not produced the clear lactate-performance changes he sees with metformin.”