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“In this Aliquot, Drs. Peter Attia, Stuart Phillips, Morgan Levine, Brad Schoenfeld, Michael Snyder, Valter Longo, Martin Gibala, George Church, as well as Kevin and Darya Rose and myself, share our strategies for finding our fitness.”

“Sleep is critical to human survival. Sleep deprivation has marked effects on glucose metabolism. Even a single night of partial sleep deprivation can induce insulin resistance and raise blood glucose levels. In this clip, Dr. Rhonda Patrick describes her personal experience with sleep deprivation and her subsequent altered metabolism.”

“Cancer cells exploit the regenerative capacity of telomerase to perpetually divide, essentially becoming immortal. In this clip, Dr. Elissa Epel discusses how having an optimal ratio of telomerase – high enough to reduce the risk of chronic disease, but low enough to reduce the risk of cancer – is key.”

“Continued physical, social, and intellectual engagement offers a practical way to support multiple parts of peakspan throughout later life, while the framework helps people think about function one domain at a time.”

“When humans ingest these compounds, our cells "read" their chemical signals and switch on cellular mechanisms that protect us not only from the plant compound but also the environmental stressors to which we are exposed on a daily basis, such as air pollution or overexposure to UV radiation.”

“What might be a surprise is that the body's response to carbohydrate and other components of the diet is highly personal – influenced by not only a person's metabolic profile, but also their gut microbiome.”

“People that used the sauna 2-3 times per week had a 20% lower risk of Alzheimer’s disease, and those that used the sauna 4-7 times per week had a 60% lower risk of Alzheimer's disease, compared to men that used the sauna 1 time per week.”

“However, critical metabolic differences between mice and humans make it difficult to extrapolate these findings to humans. In this clip, Dr. Guido Kroemer describes the current state of knowledge about the minimum amount of time required for fasting-induced autophagy in humans.”

“Although exercising animals are less likely to have cardiovascular disease or diabetes, they still experience cancer and kidney disease, it's difficult to extrapolate (or discount) the effects of exercise.”

“In fact, some clinical studies demonstrate that people who have a healthy weight exhibit better glucose control, insulin, and the ability to accrue and maintain muscle mass with intermittent fasting, although not to the extent observed in overweight people.”