Search results for autophagy

“Drugs commonly used to treat depression also reactivated autophagy in this brain region. Additional experiments indicated that autophagy helps regulate brain cell activity by breaking down excess glutamate receptors, which are often overactive in depression.”

“Related Resources Learn more about how the gut microbiome regulates immune cell production, including regulatory T cells, in this video. Learn more about how autophagy improves cancer surveillance by the immune system in this clip with Dr. Guido Kroemer.”

“The primary goal of autophagy is to allow the cell to adapt to changing conditions and external stressors, including energy deficit. The study involved 15 overweight or obese men between the ages of 30 and 50 years.”

“Dr. Valter Longo on Resetting Autoimmunity and Rejuvenating Systems with Prolonged Fasting & the FMD. Interview discussing the cellular clean-up program autophagy: Dr. Guido Kroemer on Autophagy, Caloric Restriction Mimetics, Fasting & Protein Acetylation.”

“Aging NAD+ depletion may drive the hallmarks of aging, including decreased autophagy, increased DNA damage, increased mitochondrial dysfunction, and dysregulated nutrient sensing. Depletion of NAD+ may predispose organisms to various age-related diseases, including neurodegenerative diseases, metabolic diseases, and cancer.”

“The polyphenols in olive oil activate autophagy, which leads to the clearance of plaques and tangles in the brain. Last week, I interviewed an expert on autophagy and we discussed how one of the most important functions of it is to clear away protein aggregates.”

“Mice that ate on a time-restricted schedule had fewer active genes involved in inflammation and oxidative stress and more active genes involved in metabolism and autophagy – a cellular defense mechanism.”

“Urolithin A Rejuvenates the Aging Immune System Mitochondria are central to healthy immune system aging; specifically, the ability to recycle old, dysfunctional mitochondria and replace them with new ones, termed "mitophagy" (mitochondrial autophagy).”

“A double-blind, placebo-controlled trial finds that supplementation with spermidine, a compound known to enhance autophagy, improved memory performance in older individuals after three months compared to placebo (pilot study).”

“In this way, long-term exercise training leads to more and healthier mitochondria. Mitophagy is a similar process to autophagy, which is enhanced during intermittent fasting or periods of low energy availability.”