Search results for opioid

The opioid pathway (kappa, mu, delta) and its agonism and antagonism.

“The body produces an opioid called dynorphin, which is generally responsible for dysphoria, a profound sense of unease or dissatisfaction. The binding of dynorphin to kappa-opioid receptors triggers cellular events that promote pain and distress.”

“Sauna use promotes robust increases in beta-endorphins. The body also produces an opioid called dynorphin, which is generally responsible for dysphoria, a profound sense of unease or dissatisfaction. Dynorphin also mediates the body's response to heat, helping the body to cool.”

“While there's no "alcoholism gene," several gene variants have been associated with this condition. For example, people with one variant of the mu-opioid receptor (which is involved in the brain's reward circuitry) experience a large dopamine increase when they consume alcohol.”

“These molecules play a significant role in generating the euphoric sensations often felt during moderate- to vigorous-intensity aerobic exercise. Additionally, exercise triggers the release of beta-endorphins, the body's own opioids that help reduce pain and enhance mood, famously associated with the "runner's high."”

“FTA: > On average, states allowing the medical use of marijuana have lower rates of deaths resulting from opioid analgesic overdoses than states without such laws. Opioid analgesics, such as OxyContin, Percocet and Vicodin, are prescribed for moderate to severe pain, and work by suppressing a person’s perception of pain.”

“Several neurotransmitters, including gamma-aminobutyric acid, endogenous opioids, norepinephrine, and serotonin, among others, work in concert in a series of negative feedback loops to modulate the activation of the HPA axis.”

“FTA: > Treatment for opioid addiction tampers with the testosterone levels of male but not female opioid users, a study reveals. Low testosterone in men has been associated with poor quality of life as well as erectile dysfunction, fatigue, and mood disturbances.”

“> Nielsen: We found there were quite a few animal studies (nineteen in total) that examined the synergistic effects of opioids and cannabinoids, and almost all of these confirmed that by combing opioids and cannabinoids, much lower doses of opioids are needed for effective pain relief.”

“Consumption of refined sugar dampened the reward associated with opioids (in mice) and may promote consumption of higher quantities. Oxycodone is also highly addictive. The U.S. National Survey on Drug Use and Health revealed that approximately 27.9 million people aged 12 or older used oxycodone products.”