This podcast is about one of the most important biological pathways you could possibly take the time to learn about: the NRF2 pathway.

A modest change on the "micronutrient smoothie" that also talks about the beneficial compounds that don't qualify as micronutrients.

Dr. Rhonda Patrick speaks with Dr. Satchin Panda, a professor at the Salk Institute for Biological Studies in La Jolla California. Satchin's work deals specifically with the timing of food and it's relationship with our biological clocks, which are governed...

This episode features a discussion with MedCram co-founder Kyle Allred about all things sauna. From sauna's use as an exercise mimetic to its anti-inflammatory, mood-elevating, and detoxifying properties.

Dr. Rhonda Patrick speaks with Dr. Valter Longo, a professor of gerontology and biological sciences and director of the longevity institute at the University of Southern California.

David Sinclair, PhD, is a professor in the Department of Genetics at Harvard Medical School and co-director of the Paul F. Glenn Center for the Biological Mechanisms of Aging. His work focuses on understanding the mechanisms that drive human aging and ident...

In this episode, Rhonda explains what NAD+, why it is so important for aging and why it declines with age. She discusses some of the popular NAD+ boosters like nicotinamide riboside and nicotinamide mononucleotide, what animal and human data says and some c...

This is a video on how to plausibly increase the sulforaphane created from the glucoraphanin in your broccoli sprouts by up to 3.5-fold.

Matthew Walker, Ph.D., is a professor of neuroscience and psychology at the University of California, Berkeley, and serves as the Director of the Center for Human Sleep Science. Formerly, Dr. Walker served as a professor of psychiatry at the Harvard Medical...

Dr. Rhonda Patrick discusses how conditioning the body to heat stress through sauna use, called "hyperthermic conditioning" may cause adaptations that increase athletic endurance (by increasing plasma volume and blood flow to heart and muscles) and potentia...

In this video, Dr. Rhonda Patrick summarizes a recent study that found that frequency of sauna use was associated with increased decreased risk of death. Using the sauna 2-3 times per week was associated with 24% lower all-cause mortality and 4-7 times per ...

The production of melatonin begins to increase 2-3 hours before our normative bedtime, which may be a signal to the pancreas to begin suppressing the production of insulin.

Dr. Bredesen’s is known for his work in translating his scientific research into effective treatments for Alzheimer’s disease. He is the author of the book The End of Alzheimer's and the ReCODE protocol – reversal of cognitive decline – a protocol that offe...

Broccoli sprouts contain more glucoraphanin, the precursor to sulforaphane, than mature broccoli. Glucoraphanin activates the Nrf2 pathway to protect cells from oxidative stress and damage. In this episode, we describe the basics of sprouting broccoli seeds.

Dr. Peter Attia is the founder of Attia Medical, a medical practice with offices in San Diego and New York City, focusing on the applied science of longevity and optimal performance.