Related Episodes for APOE 3/4 and APOB and their influence on Alzheimer’s and cardiovascular disease | Peter Attia

“Uric acid adds another long-range signal. In the Swedish AMORIS cohort, 1,224 people who reached age 100 tended to have lower midlife glucose, creatinine, and uric acid than peers who did not become centenarians.”

“Older adults can have anabolic resistance and may need more protein per meal to reach a leucine threshold; Dr. Schoenfeld discusses roughly 2–3 grams of leucine as a flexible estimate, not a hard cutoff or a reason everyone needs isolated leucine.”

“A 2025 meta-analysis found improved quality of life, no clear overall change in ejection fraction, and a borderline improvement in New York Heart Association functional class across a small set of trials.”

“Dr. Patrick also distinguishes general-population evidence from people with diabetes or insulin resistance, where some observational studies report different risk patterns and residual confounding remains substantial.”

“Peak plasma flavan-3-ol metabolites after the banana smoothie were 84 percent lower than after the capsule, while the low-PPO berry smoothie produced levels similar to the capsule. PPO is released when plant tissue is cut, bruised, or blended and can react with selected polyphenols before they reach circulation.”

“Longer endurance aerobic exercise seems to be most effective at producing higher levels of FGF21, coinciding with anecdotes you might have heard from runners who have successfully used exercise in this sort of way. Relevant publications Flippo, Kyle H., et al.”

“In this clip from Q&A #68, Dr. Rhonda Patrick compares stearic, palmitic, myristic, and lauric acids and explains why chocolate, cheese, butter, and coconut oil can produce different lipid responses.”

“A separate study of 17 recently abstinent heavy cannabis users found poorer sleep efficiency, longer sleep onset, and less slow-wave sleep than in 14 drug-free controls, consistent with withdrawal-related sleep disruption.”