APOE4 allele linked with impairment of deep sleep and deadly sleep apnea | Matthew Walker

Parent Episode: Dr. Matthew Walker on Sleep for Enhancing Learning, Creativity, Immunity, and Glymphatic System

APOE4, one of three common genetic variants of the APOE (apolipoprotein E) gene, is present in approximately 10 to 15 percent of people. Having one or more APOE-4 alleles markedly increases a person's risk of developing Alzheimer's disease. Adding to this risk is apnea, a common sleep problem in which a person temporarily stops breathing. Apnea interferes with deep sleep, induces hypoxia, and promotes amyloid-beta accumulation in the brain. In this clip, Dr. Matthew Walker describes the dual risk of carrying the APOE4 allele and having sleep apnea.

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