APOE4 allele linked with impairment of deep sleep and deadly sleep apnea | Matthew Walker
APOE4, one of three common genetic variants of the APOE (apolipoprotein E) gene, is present in approximately 10 to 15 percent of people. Having one or more APOE-4 alleles markedly increases a person's risk of developing Alzheimer's disease. Adding to this risk is apnea, a common sleep problem in which a person temporarily stops breathing. Apnea interferes with deep sleep, induces hypoxia, and promotes amyloid-beta accumulation in the brain. In this clip, Dr. Matthew Walker describes the dual risk of carrying the APOE4 allele and having sleep apnea.
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