Related Episodes for Creatine, Rhodiola, and Ashwagandha for Performance and Recovery

“The main ingredient-interaction evidence concerns polyphenol oxidase. A small controlled crossover study found that a high-PPO banana smoothie greatly reduced circulating flavan-3-ol metabolites compared with a low-PPO berry drink or capsule control.”

“Davidson reported that five minutes of daily Healthy Minds Program practice for 28 days produced a significant decrease in interleukin-6 (IL-6), a pro-inflammatory cytokine, measured three months after the formal intervention ended and compared with an untreated control group.”

“Human trials suggest that alpha-lipoic acid can modestly improve selected lipid measures. A dose-response meta-analysis of 12 studies found reductions in total cholesterol, LDL cholesterol, and triglycerides across doses from 300 to 1,200 milligrams per day.”

“Dr. Patrick's practical answer is to use black coffee, a small amount of cream or MCT, or an unsweetened plant milk when frequent additions worsen the lipid tradeoff, and to assess ApoB rather than assume an additive is harmless.”

“But evidence suggests that supplemental vitamin D in lactating women can increase breast milk concentrations to levels that are adequate to reduce the risk of deficiency in breastfed infants. In this clip, Dr. Rhonda Patrick describes the data suggesting that maternal supplemental vitamin D can reduce the risk of deficiency in breastfed infants.”

“Similarly, the timing of eating and exercise, especially in elite athletes, has not been studied and may, in fact, require self-experimentation by the athletes as they find the perfect interval of fasting to support their optimal performance.”

“A national survey analysis estimated 2.6% severe deficiency, 22% moderate deficiency, and 40.9% insufficiency among US adults, although prevalence changes with the threshold used. These categories should remain distinct because insufficiency is not the same as clinical deficiency.”

“A 12-month randomized controlled trial found that vitamin D supplementation improved cognitive function, intelligence quotient scores, telomere length, and lowered oxidative stress markers in older adults with mild cognitive impairment (compared to placebo), suggesting that not only does vitamin D supplementation improve biomarkers of aging, but also functional outcomes.”

“In a four-month randomized trial of 88 overweight, untrained middle-aged adults, daily doses of 500 or 1,000 milligrams improved some muscle and mitochondrial measures, while the primary outcome of peak power did not significantly improve.”

“Choosing a supplement that contains both glucoraphanin (the precursor to sulforaphane), as well as myrosinase (the enzyme that converts glucoraphanin to sulforaphane), is crucial to ensuring optimal sulforaphane delivery.”