Related Episodes for The 'Big Mac effect:' the unhealthy combination of refined carbohydrates and saturated fat

“The impact of the ketogenic diet on gut bacteria has not been actively studied. In animal models high-fat diets are thought to provoke the release of endotoxin from bacterial cell membranes resulting in negative health consequences. In this clip, Dr. Dominic D'Agostino and Dr. Rhonda Patrick discuss the ketogenic diet and its implications for gut health.”

“Lunch varied among sardines, mackerel, wild salmon, avocado, nuts, fruit, cheese, and quinoa salad, giving her flexible sources of protein, marine fats, fiber, and fermented foods. Dinner typically paired fish, chicken, or occasional beef with vegetables or salad.”

“Conventional health advice, such as healthy eating, physical activity, and education level are linked with slowed epigenetic aging, albeit weakly, and obesity, sleep deprivation, and smoking are linked with accelerated epigenetic aging.”

“In this Institute for Functional Medicine excerpt, Dr. Rhonda Patrick says about half of U.S. adults do not meet adequate magnesium intake and gives an average adult RDA near 400 milligrams per day, with sex-specific variation.”

“A 2025 network meta-analysis of 217 randomized trials and 15,684 people with knee osteoarthritis found that aerobic exercise was likely the most beneficial exercise category for pain, function, gait, and quality of life.”

“Other observational research in women has associated healthier dietary patterns with modestly lower acceleration on PhenoAge and GrimAge, while large prospective studies associate greater fruit and vegetable intake with lower cardiovascular and all-cause mortality.”

“Inflammation, a downstream consequence of insulin resistance, promotes the formation of reactive oxygen species and other damaging molecules, which can enter the brain via the lymphatic system.”

“While it’s likely that there may be more going on with depression than just inflammation by itself, it could be an incredibly useful lens through which to look at promising avenues to potentially treat or prevent it, since controlling systemic inflammation shows promise as being both important for longevity and health in general.”

“Few topics come up in their discussion where Dr. Fahey doesn't have an anecdote about a study he was involved in, or, in some cases, "tribal knowledge" that may not even be published but is nonetheless interesting and an important part of the story that is unique to his particular vantage point.”

“00:29:20 - Organs shrink during fasting and then regrow after refeeding. Study. 00:29:45 - Fasting stresses healthy cells so they increase their stress-response pathways, including heat shock proteins, antioxidant production, and anti-inflammatory.”