Related Episodes for Breakfast skipping and late-night eating (after 7PM) linked to poorer metabolic health | Ruth Patterson

“In this brief episode, we learn how restoring our dietary and sleep pattern to one that more closely syncs with those imposed by nature, especially by avoiding eating within 2-3 hours before bed and onset of melatonin production, may improve our health and potentially prolong our healthspan.”

“Whether metformin reduces the risk of cancer in healthy people remains to be seen. In this clip, Dr. Rhonda Patrick describes the relationship between metformin and cancer incidence and the relevance for those with type 2 diabetes.”

Dr. Michael Snyder discusses personalized medicine and the use of technologies that monitor metabolism and other health markers.

“The gut-brain axis, the bidirectional signaling pathway between the gastrointestinal tract and the nervous system, modulates the body's stress response. A key player in this pathway is the gut microbiome, the collection of genomes of the microorganisms that exist in the gastrointestinal tract.”

“While Dr. Rhonda Patrick’s first video focused primarily on the micronutrients found in the various fruits and vegetables she put in her smoothie, this one, in addition to offering some modest changes on the recipe, instead focuses on the beneficial “hormetic” compounds that are NOT micronutrients.”

“A meta-analysis of resistance-training trials found that protein supplementation produced modest additional gains in strength and fat-free mass, with average fat-free-mass benefit plateauing near 1.62 g/kg/day. This is a group estimate, not a precise requirement for every older adult.”

“The inclusion of active myrosinase is critical in clinical trials because although myrosinase-producing gut bacteria can convert unhydrolyzed glucosinolates to their cognate isothiocyanates, the conversion rate is highly variable and subject to interindividual differences in gut bacteria populations.”

“Conversely, animal studies suggest that caloric restriction may slow epigenetic aging. In this clip, Dr. Steve Horvath describes research suggesting that caloric restriction in animals, although it is unclear this will translate to humans.”

“It remains unknown whether these levels are sufficient for optimal immunological functioning. A large meta-analysis of 32 studies, spanning nearly 50 years, suggests that 25-hydroxyvitamin D levels below 30 ng/mL are associated with a higher risk of death from all causes.”

“Dr. Patrick also discusses STEP 5, in which two years of treatment produced about 15.2 percent loss versus 2.6 percent with placebo, with the curve leveling while participants remained on treatment. Dual GIP/GLP-1 therapy can produce still larger losses in some trials.”