Related Episodes for Exercise causes aging molecules to shift | Dr. Michael Snyder

“01:52:55 - Environmental enrichment creates epigenetic changes that benefit learning and memory in rodents and these benefits transfer to offspring. Study. 02:05:00 - NASA study showed that gravity influenced expression of genes involved in metastasis.”

“02:03:18 - A recent study measured omega-3 fatty acid levels from both supplemental and dietary sources in blood and found that for every 1 percent increment in omega-3 fatty acid levels there was a 20 percent decreased risk in all-cause mortality.”

“New Scientist article. 02:06:10 - Some people, like Tom Cruise and Keanu Reeves, seem to defy aging. 02:08:15 - One 12-ounce can of sugar-sweetened soft drink per day shortened telomere length, corresponding to 4.6 years of biological aging.”

“Some of the factors contributing to these variable phenotypes include persistent damage to our DNA and mitochondrial dysfunction, driven by an altered NAD:NADH ratio, the latter of which has recently been shown to be improved by certain dietary supplements like nicotinamide riboside.”

“Dr. Patrick also discusses glucose, HbA1c, fasting insulin, kidney and electrolyte markers, hs-CRP, fibrinogen, thyroid tests, CBC, vitamin D, sex hormones, IGF-1, and the Omega-3 Index.”

“Because red blood cells turn over slowly, the test provides a longer-term view of marine omega-3 status than a recent meal and gives people a measurable way to evaluate diet or supplementation.”

“A later Framingham analysis followed 2,240 adults for 11 years and found that a red-cell fatty acid model including the Omega-3 Index predicted all-cause mortality about as well as a model using several standard cardiovascular risk factors.”

“The mast cells release pro­inflammatory cytokines and proteases that damage the gut, leading to intestinal permeability, a condition otherwise known as “leaky gut.” This leakiness allows bacteria and bacterial antigens to cross the gut’s inner layer, the epithelium, and activate even more immune cells, leading to more inflammation – a key driver in the aging process.”

“While Dr. Rhonda Patrick’s first video focused primarily on the micronutrients found in the various fruits and vegetables she put in her smoothie, this one, in addition to offering some modest changes on the recipe, instead focuses on the beneficial “hormetic” compounds that are NOT micronutrients.”

“The question of whether NAD+ is derived directly from NR or NMN in certain tissues rather than being salvaged from nicotinamide may, in particular, have implications for whether or not oral administration may be hampered in achieving maximal NAD+ status due to the fact that the process of salvaging NAD+ from nicotinamide is subject to feedback inhibition.”