Related Episodes for Non-pharmaceutical approach to lowering hemoglobin A1c using time-restricted eating | Ruth Patterson

“The body has elegant mechanisms that allow it to utilize non-carbohydrate substrates to generate glucose. Gluconeogenesis is a metabolic pathway in which the liver produces glucose from non-carbohydrate substrates including glucogenic amino acids (from protein) and glycerol (from lipids).”

“In this clip from Dr. Rhonda Patrick's appearance on The Diary of a CEO, she explains that a shorter eating window can make calorie reduction easier, while a longer overnight fast shifts fuel use toward fatty acids and ketones.”

“In a 7.5-week randomized trial of 39 adults with overweight or obesity, a 13-to-16-hour overnight fast that ended food intake at least three hours before habitual sleep improved nighttime diastolic blood-pressure dipping by about 3.5 percent and lowered nighttime diastolic pressure by about 1.8 mm Hg.”

“Mouse studies of feeding during infection also found different responses across bacterial and viral models, so a minimally processed dietary pattern, regular exercise, and normal hydration and nutrition during illness provide a more useful foundation than one universal food or fasting rule.”

“00:29:20 - Organs shrink during fasting and then regrow after refeeding. Study. 00:29:45 - Fasting stresses healthy cells so they increase their stress-response pathways, including heat shock proteins, antioxidant production, and anti-inflammatory.”

“Some of the factors contributing to these variable phenotypes include persistent damage to our DNA and mitochondrial dysfunction, driven by an altered NAD:NADH ratio, the latter of which has recently been shown to be improved by certain dietary supplements like nicotinamide riboside.”

“I am simply saying you would be even more healthy if you also included fiber...if you also included fruits and vegetables.” - Layne Norton, Ph.D. The Carnivore Diet Eating an all meat or all animal product diet—commonly referred to as the carnivore diet—has been hailed by many as the only diet that’s provided a cure for their autoimmune disease or other health issues.”

“In this brief episode, we learn how restoring our dietary and sleep pattern to one that more closely syncs with those imposed by nature, especially by avoiding eating within 2-3 hours before bed and onset of melatonin production, may improve our health and potentially prolong our healthspan.”

“The good news is that extending sleep by ~1 hour per night has been shown to improve insulin sensitivity, normalize levels of appetite-regulating hormones, reduce cravings for sweet and salty foods, decrease sugar consumption, lower caloric intake, and aid in weight loss.”

“Conversely, animal studies suggest that caloric restriction may slow epigenetic aging. In this clip, Dr. Steve Horvath describes research suggesting that caloric restriction in animals, although it is unclear this will translate to humans.”