Related Episodes for Why people age at different rates and how menopause and obesity contribute | Dr. Morgan Levine

“However, the term "fasting" can comprise a variety of subtypes. Intermittent fasting, a term lacking specificity, usually refers to interventions such as alternate-day fasting, fasting one day per week, or a five:two eating pattern (fasting for two days per week).”

“The most compelling human signal appears when the brain is under acute strain. In a randomized crossover study, a single dose of 0.35 grams per kilogram during 21 hours of sleep deprivation changed cerebral energy metabolites and preserved selected measures of cognitive performance.”

“Healthy, well-nourished adults can usually synthesize enough, and athlete trials have not found consistent improvements in immune measures, aerobic performance, body composition, or intestinal permeability from routine supplementation.”

“00:20:21 - Some of the key blood-based biomarkers that are useful for tracking and projecting future cognitive health, including: homocysteine (<7μml/L preferred), which Dr. Bredesen indicates may be a mediator of cerebral atrophy, and also fasting insulin (<5% preferred), hemoglobin A1c, fasting glucose, vitamin D, and a number of other hormones relevant for trophic support.”

“Dr. Rhonda Patrick discusses the differences between different forms of DHA in terms of bioavailability and transport into different cells. She talks about why a specific type of DHA (DHA in phosphatidylcholine) is more readily transported into the brain because it forms DHA-lysophsophatidylcholine.”

“In this clip, Dr. Ruth Patterson describes how eating following the body's circadian clock, eating during the day and fasting at night, enables the body to focus on repair rather than on the digestion of food.”

“Her practical message is to reduce the frequency and size of large glucose exposures. Foods with intact fiber, protein, and minimally processed carbohydrates digest more slowly than refined added sugar, while regular exercise gives skeletal muscle a large destination for circulating glucose.”

“In a two-year trial of 237 postmenopausal women, approximately 9 to 10 grams per day combined with resistance training and walking did not add a bone-density benefit, so its role is better framed around muscle and physical function.”

“In this excerpt from Dr. Rhonda Patrick's A4M LongevityFest 2023 keynote, she argues that vigorous exercise is one of the most powerful tools for healthy aging because it can raise cardiorespiratory fitness.”

“In 27 men with metabolic syndrome, four four-minute intervals near 90 percent of peak heart rate improved VO2 max more than work-matched moderate exercise. A two-year randomized trial used a broader progressive program in healthy, sedentary adults around age 53.”