Related Episodes for How Nicotinamide Riboside Raises NAD

“Longer-term nutrient status offers another perspective: in a randomized trial of adults with overweight or obesity, 15 grams of psyllium daily for three months did not significantly alter serum micronutrient concentrations relative to control.”

“In a six-month trial of adults with peripheral artery disease, a flavanol-rich cocoa beverage improved six-minute walking distance measured 2.5 hours after dosing. In older adults with mild cognitive impairment, higher-flavanol cocoa improved selected verbal-fluency and executive-function tests over eight weeks.”

“However, the term "fasting" can comprise a variety of subtypes. Intermittent fasting, a term lacking specificity, usually refers to interventions such as alternate-day fasting, fasting one day per week, or a five:two eating pattern (fasting for two days per week).”

“The most compelling human signal appears when the brain is under acute strain. In a randomized crossover study, a single dose of 0.35 grams per kilogram during 21 hours of sleep deprivation changed cerebral energy metabolites and preserved selected measures of cognitive performance.”

“A recent meta-analysis also found small benefits in selected cognitive domains, including memory and processing speed, with responses that may depend on age, diet, baseline stores, stress, dose, and the cognitive test used.”

“A separate six-week randomized study in 30 healthy young adults found that neither 10 nor 20 grams per day improved the tested cognitive outcomes compared with placebo. The result is an important counterweight to the acute sleep-deprivation experiment.”

“Healthy, well-nourished adults can usually synthesize enough, and athlete trials have not found consistent improvements in immune measures, aerobic performance, body composition, or intestinal permeability from routine supplementation.”

“00:20:21 - Some of the key blood-based biomarkers that are useful for tracking and projecting future cognitive health, including: homocysteine (<7μml/L preferred), which Dr. Bredesen indicates may be a mediator of cerebral atrophy, and also fasting insulin (<5% preferred), hemoglobin A1c, fasting glucose, vitamin D, and a number of other hormones relevant for trophic support.”

“Tools, companies, and resources mentioned OpenAI - AI research and deployment company behind widely used GPT systems and developer tools; its science case study describes GPT-5 helping Unutmaz's lab resolve a long-standing immunology question.”

“Dr. Patrick explains that she uses zinc lozenges only during exposure or the earliest signs of illness, often totaling roughly 80 to 100 milligrams per day for a short period. Small randomized zinc-acetate lozenge trials have produced mixed results, with one reporting a shorter cold and another finding no faster recovery with more adverse effects.”