Related Episodes for Intestinal Permeability: the Bacterial link to Aging, Brain Barrier Dysfunction & Metabolic Disorder

“Brady Holmer turns the protocol into a weekly framework: one interval session, one longer easy session, additional base-pace activity, active recovery, and at least two resistance sessions. Dr. Patrick emphasizes the progressive build.”

“These transient stressors induce the expression of genes that process inflammatory molecules. In this clip, Tim Ferriss and Dr. Rhonda Patrick discuss acute versus chronic inflammation and how supplemental antioxidants can negate some of the benefits of exercise.”

“The bar was formulated to be moderate in calories (107 kcal/≈25 g bar), but nutrient dense, with a polyphenolic-rich matrix of fruit, walnuts, and non-alkali-processed dark chocolate, supplemental vitamins, minerals, docosahexaenoic acid (DHA), a blend of insoluble and soluble fibers, protein, and glutamine.”

“Chronic inflammation as a contributor to aging is not an especially new idea. Here, too, epigenetic clock evidence does seem to see this relationship. There is also evidence that HIV accelerates epigenetic aging.”

“Drinking two to three cups per day is linked to roughly a 60% reduced risk of developing diabetes, a statistic that highlights coffee's robust metabolic benefits that arise from its ability to activate AMP-activated protein kinase (AMPK), a critical regulator of cellular energy metabolism.”

“Other hormetic responses to cold exposure include increased production of PGC1-alpha, a protein that promotes mitochondrial biogenesis, the production of new, healthy mitochondria, and the activation of brown fat – a phenomenon once thought to occur only in newborns, but now known to occur in adults, especially after cold exposure.”

“Perhaps the most clear-cut examples of cryotherapy’s beneficial effects are observed in the brain, where levels of the hormone and neurotransmitter norepinephrine – responsible for vigilance, attention, focus, and positive mood – increase markedly when the body is exposed to extreme cold.”

“The majority of glutamine administered orally is taken up by the liver and gut, with little ending up in the bloodstream. Dr. D'Agostino discourages supplementing with glutamine for patients with cancers of the gastrointestinal tract and even recommends they avoid high glutamine containing foods.”

“A perplexing aspect of SARS-CoV-2, the novel coronavirus that causes COVID-19, is that people respond to it in disparate ways — some exhibiting no symptoms at all, and others experiencing life-threatening complications.”

“Healthy, well-nourished adults can usually synthesize enough, and athlete trials have not found consistent improvements in immune measures, aerobic performance, body composition, or intestinal permeability from routine supplementation.”