Related Episodes for Joe Rogan Experience #568 - Dr. Rhonda Patrick

“More than 200 HMOs have been identified, and they are the third most abundant factor in breast milk after fat and lactose. The primary role of HMOs is to serve as prebiotics – compounds that induce the growth or activity of beneficial bacteria.”

“In this talk, we’ll be exploring the intersection between genetics, nutrition, and environment: how your diet, micronutrients, exercise, heat stress, and sleep can change the expression of your genes and how this has profound effects on the way your body functions and ages.”

“While it’s likely that there may be more going on with depression than just inflammation by itself, it could be an incredibly useful lens through which to look at promising avenues to potentially treat or prevent it, since controlling systemic inflammation shows promise as being both important for longevity and health in general.”

“Circulating LPS can also bind to lipoproteins, facilitating their absorption in the liver during LDL recycling, effectively removing LPS from circulation and lowering systemic inflammation – a phenomenon demonstrated mechanistically with statins that increase lipoprotein recycling by increasing LDL receptors.”

Jim Kean is the CEO of National Pro Grid League (NPGL) and founder of WellnessFX.

“00:29:20 - Organs shrink during fasting and then regrow after refeeding. Study. 00:29:45 - Fasting stresses healthy cells so they increase their stress-response pathways, including heat shock proteins, antioxidant production, and anti-inflammatory.”

“01:52:55 - Environmental enrichment creates epigenetic changes that benefit learning and memory in rodents and these benefits transfer to offspring. Study. 02:05:00 - NASA study showed that gravity influenced expression of genes involved in metastasis.”

“New Scientist article. 02:06:10 - Some people, like Tom Cruise and Keanu Reeves, seem to defy aging. 02:08:15 - One 12-ounce can of sugar-sweetened soft drink per day shortened telomere length, corresponding to 4.6 years of biological aging.”

“Some of the factors contributing to these variable phenotypes include persistent damage to our DNA and mitochondrial dysfunction, driven by an altered NAD:NADH ratio, the latter of which has recently been shown to be improved by certain dietary supplements like nicotinamide riboside.”

“When this barrier breaks down, as in, intestinal permeability, also known as "leaky gut," microbes and their metabolites translocate out of the intestinal lumen and influence the health and function of distant tissues, such as the brain, connective tissues, sometimes promoting a state known as "metabolic endotoxemia."”