Related Episodes for Lack of sleep decreases immune system effectiveness — ~30% drop in Natural Killer T cell activity | Matthew Walker

“Antibody-dependent enhancement (ADE) occurs when the immune system generates non-functional antibodies that bind to a pathogen, intensifying inflammation and tissue damage without neutralizing the pathogen.”

“Activation of this important system of immunosurveillance is a predictor of the long-term efficacy of chemotherapy and may help to explain the complex relationship of autophagy with cancer, wherein the initial suppression of autophagy may help prevent attracting undue attention from the immune system, but may later facilitate ongoing transformation.”

“Unique qualities of the marine omega-3 fatty acids EPA and DHA There are several omega-3 fatty acids, but the ones that have the greatest relevance for human health are the two identified in the Inuit's blood – EPA and DHA – as well as alpha-linolenic acid (ALA), which is found in a wide variety of seeds, nuts, and their oils.”

“Three of the most common human diseases are cardiovascular disease, cancer, and Alzheimer's disease. The most significant drivers of cardiac disease are smoking, hypertension and elevated APOB, a biomarker of LDL particle number.”

“Blood type is determined by what kind of antigens are presented on the outside of our blood cells. Blood can either be type A, B, AB, or O. Early data suggest that people with blood type A are at higher risk of developing COVID-19, but those with blood type O are at lower risk. In this clip, Dr. Rhonda Patrick describes the different blood types and how they influence immunity.”

“Additionally, we also discuss the important role magnesium plays in preventing random mutations. "Men with the highest quartile of magnesium levels have a 40% decrease in all-cause mortality and a 50% decrease in deaths from cancer.".”

“Autophagy is thought to be part of a coordinated biological process that is important for exposing cancer cells to the immune system, ultimately leading to their weakening and death. However, the relationship between autophagy and cancer is complicated.”

“Dr. Patrick also revises an earlier concern about acrylamide: although roasting can form it, the human evidence she reviews does not show that ordinary coffee intake raises cancer risk, and the overall epidemiology points in the opposite direction for several cancers.”

“Perhaps the most clear-cut examples of cryotherapy’s beneficial effects are observed in the brain, where levels of the hormone and neurotransmitter norepinephrine – responsible for vigilance, attention, focus, and positive mood – increase markedly when the body is exposed to extreme cold.”

“However, the term "fasting" can comprise a variety of subtypes. Intermittent fasting, a term lacking specificity, usually refers to interventions such as alternate-day fasting, fasting one day per week, or a five:two eating pattern (fasting for two days per week).”