Related Episodes for Lack of sleep linked to glucose insensitivity and pre-diabetes | Matthew Walker

“Autophagy is an intracellular degradation system involved in the disassembly and recycling of unnecessary or dysfunctional cellular components. Fasting – even short periods of overnight fasting that occurs during time-restricted eating – induces autophagy, providing a kind of daily maintenance for the body.”

“Dr. Rhonda Patrick – who wears a continuous glucose monitor – has found that her post-smoothie blood glucose levels are markedly lower when her smoothie contains moringa powder. In this clip, Dr. Rhonda Patrick shares anecdotal evidence that moringa reduces blood glucose levels.”

“Dom's efforts at teasing out the differences between induced nutritional ketosis (through a low carbohydrate, high fat diet) and ketosis from the dietary introduction of exogenous ketones, like beta-hydroxybutyrate, especially in the context of therapeutic and performance enhancing effects.”

“Her practical message is to reduce the frequency and size of large glucose exposures. Foods with intact fiber, protein, and minimally processed carbohydrates digest more slowly than refined added sugar, while regular exercise gives skeletal muscle a large destination for circulating glucose.”

“For example, growing up in an overly hygienic environment increases a child's risk for developing autoimmune diseases, but exposure to dirt, especially from soil, pets, and roaches, in the first year of life may provide protection against asthma and allergy-related skin disease.”

“One of the mechanisms behind the beneficial effects of exercise is its ability to induce autophagy in skeletal muscle and, potentially, other organs. In this clip, Dr. Guido Kroemer describes the anti-diabetes and anti-obesity effects of exercise-induced autophagy.”

“In this clip, Drs. Levine and Patrick discuss genetic and environmental factors that can accelerate or slow epigenetic aging. Dr. Levine also discusses the aging clock she created and how it can be used, along with other biomarkers, to determine an individual's rate of aging.”

“During about eight years of follow-up, the models associated one vigorous minute with roughly 4.1 moderate minutes for all-cause mortality, 7.8 minutes for cardiovascular mortality, and 9.4 minutes for type 2 diabetes risk.”

“Across the modeled dose-response curves, one vigorous minute corresponded to 4.1 moderate minutes for all-cause mortality, 7.8 for cardiovascular mortality, 5.4 for major cardiovascular events, 9.4 for incident type 2 diabetes, and 3.5 for cancer mortality.”

“Insulin-like growth factor 1 (IGF-1) promotes the growth of existing cancer cells and contributes to aging, but also has some beneficial functions. IGF-1 is required for the growth and repair of muscles and is also necessary for producing new brain cells.”