Related Episodes for Similarities between lactate and beta-hydroxybutyrate for traumatic brain injury | Dominic D'Agostino

“High energy demand is a promising research setting. In a randomized crossover study of 15 healthy adults undergoing 21 hours of sleep deprivation, a single 0.35-gram-per-kilogram dose changed cerebral energy measures and improved selected cognitive outcomes.”

“Time-restricted eating can help some people reduce eating opportunities, although a 12-month trial found no additional weight or body-fat benefit when an eight-hour eating window was added to calorie restriction. Sleep also affects appetite and fat distribution.”

“This is a proposed metabolic advantage, not proof of slower brain aging. Small TBI trials found that sodium lactate lowered intracranial pressure more than mannitol in severe TBI and improved cognitive scores more than 3% sodium chloride in mild TBI.”

“She uses that result to make consistency practical. Aerobic exercise does not need to be all-out every day, but sessions that raise heart rate and improve cardiorespiratory fitness provide a meaningful brain stimulus.”

“In 15 people with severe traumatic brain injury, sodium lactate infusion increased brain lactate, pyruvate, and glucose without raising intracranial pressure, and a randomized study in 60 patients with mild traumatic brain injury reported better cognitive recovery than hypertonic saline.”

“Mouse studies of feeding during infection also found different responses across bacterial and viral models, so a minimally processed dietary pattern, regular exercise, and normal hydration and nutrition during illness provide a more useful foundation than one universal food or fasting rule.”

“In the prospective Framingham Offspring Study, people in the highest red-blood-cell DHA group had approximately 49 percent lower risk of developing Alzheimer's disease than those in the lowest group.”

“A separate trial of 153 adults found that smartphone-based mindfulness training combining attention monitoring with acceptance reduced daily loneliness and increased social interactions compared with monitoring alone or an active control.”

“Across standardized risk reductions, the models associated one vigorous minute with roughly 4.1 moderate minutes for all-cause mortality, 7.8 minutes for cardiovascular mortality, 5.4 minutes for major cardiovascular events, and 9.4 minutes for incident type 2 diabetes.”

“Dr. Rhonda Patrick discusses how conditioning the body to heat stress through sauna use, called "hyperthermic conditioning" may cause adaptations that increase athletic endurance (by increasing plasma volume and blood flow to heart and muscles) and potentially even muscle mass. She also discusses the profound effects of hyperthermic conditioning on the brain including cognitive function.”