Related Episodes for Why You Can't Sleep (and How to Fix It) | Dr. Michael Grandner

“Although the vast majority of supplement manufacturers do not take steps to preserve the integrity of their products and some have made misleading claims about their products' efficacy, a few reputable manufacturers produce quality supplements that demonstrate beneficial effects against prostate cancer.”

“For example, while vitamin C acts primarily as an antioxidant at physiological concentrations of approximately 50 micromoles per liter, pharmacologic doses of intravenous vitamin C greater than 1 gram generate hydrogen peroxide, a type of reactive oxygen species produced by neutrophils to destroy pathogens such as viruses.”

“Autophagy is an intracellular degradation system involved in the disassembly and recycling of unnecessary or dysfunctional cellular components. Fasting – even short periods of overnight fasting that occurs during time-restricted eating – induces autophagy, providing a kind of daily maintenance for the body.”

“In a study in which fasting mice were provided either caffeinated or decaffeinated coffee in drinking water, autophagy was observed in the liver, muscle, and heart just four hours after consumption. In this clip, Dr. Guido Kroemer discusses the autophagy-inducing qualities of coffee.”

“Dr. Patrick explains that she uses zinc lozenges only during exposure or the earliest signs of illness, often totaling roughly 80 to 100 milligrams per day for a short period. Small randomized zinc-acetate lozenge trials have produced mixed results, with one reporting a shorter cold and another finding no faster recovery with more adverse effects.”

“In a two-year trial of 237 postmenopausal women, approximately 9 to 10 grams per day combined with resistance training and walking did not add a bone-density benefit, so its role is better framed around muscle and physical function.”

“In this excerpt from Dr. Rhonda Patrick's A4M LongevityFest 2023 keynote, she argues that vigorous exercise is one of the most powerful tools for healthy aging because it can raise cardiorespiratory fitness.”

“In this clip from his FoundMyFitness interview with Dr. Rhonda Patrick, Dr. Benjamin Levine explains why recovery is part of training rather than time lost between workouts. Hard sessions trigger protein synthesis, vascular signaling, and muscular remodeling, but those changes need lower-stress time to develop.”

“Researchers are studying whether consumption of the exogenous ketone ester, beta-hydroxybutyrate, may confer some of the health advantages of a ketogenic diet through its activation of PPAR-alpha, a key enzyme in the fasting response.”

“Dr. Patrick recommends vigorous intervals when moderate training does not improve an individual’s VO2 max and presents repeated one-minute efforts and the Norwegian 4-by-4 as practical options.”