Related Episodes for Minimum fasting length required for autophagy | Guido Kroemer

“The body has elegant mechanisms that allow it to utilize non-carbohydrate substrates to generate glucose. Gluconeogenesis is a metabolic pathway in which the liver produces glucose from non-carbohydrate substrates including glucogenic amino acids (from protein) and glycerol (from lipids).”

“How too much iron can lead to protein aggregation and how vitamin D can prevent it. A program, directed by Gordon, called the Caenorhabditis Intervention Testing Program which tests potential longevity compounds that may extend the lifespan of several different species of worms.”

“Dr. Rhonda Patrick talks at SF Nerd Nite about transgenerational effects of caloric restriction on longevity, B-vitamins silencing bad genes, cognitive stimulation reversing neurodegenerative disease, exercise increases neurogenesis, and ways in which vitamin D might influence aging.”

“In this member Q&A clip, Dr. Rhonda Patrick shares four practices she uses or finds compelling for healthy aging: sauna, sulforaphane-rich foods or supplements, time-restricted eating, and high-intensity interval training.”

“Earlier long-term research in older male physicians found no cognitive benefit, and the main COSMOS trial did not significantly reduce invasive cancer, cardiovascular events, or mortality over a median of 3.6 years.”

“In the 521,330-person EPIC cohort, participants in the highest country-specific quartile of coffee intake had lower all-cause mortality over an average 16.4 years than nonconsumers. The association was observational, with hazard ratios of 0.88 in men and 0.93 in women.”

“While the alcohol concentration in breast milk is low, infants cannot metabolize it very well and can cause altered sleep habits, decreased appetite, weight gain, low blood sugars, and impaired motor development.”

“A later crossover study using a lower weight-based dose found its clearest benefit in reasoning, while several memory, accuracy, fatigue, and sleepiness outcomes did not reliably improve. Routine muscle supplementation and acute sleep-loss research use different protocols.”

“A systematic review in older adults linked Mediterranean dietary patterns with lower inflammatory markers, while a meta-analysis of randomized trials found that vitamin D supplementation reduced acute respiratory infection risk overall, with the strongest protection among people who were very deficient and received regular doses.”

“In a randomized crossover study of 18 young men with overweight or obesity, ten three-minute walking or squat breaks spaced every 45 minutes across 8.5 hours lowered post-meal glucose exposure more than uninterrupted sitting or one continuous 30-minute walk.”