Related Episodes for Peter Attia, M.D. on Macronutrient Thresholds for Longevity and Performance, Cancer & More

“Antibiotic therapy is commonly used to eradicate the bacterium, but sulforaphane, an isothiocyanate compound derived from broccoli, has been shown to reduce H. pylori populations markedly, and may offer a more cost-effective means of treating H.”

“In this video Dr. Rhonda Patrick interviews Dr. Bruce Ames about his triage theory, which he proposes that the body has developed a rationing response to shortages of micronutrients (vitamins and minerals) throughout evolution.”

“Additionally, we also discuss the important role magnesium plays in preventing random mutations. "Men with the highest quartile of magnesium levels have a 40% decrease in all-cause mortality and a 50% decrease in deaths from cancer.".”

“Even though the primary endpoints failed (NR did not improve insulin sensitivity or weight loss), he notes a meaningful signal in reduced liver fat—a 2% decrease in the NR group compared to a 0.2% reduction in the placebo group, a difference that didn't reach statistical significance, likely because subjects weren't randomized by liver fat and variability was high.”

“Other hormetic responses to cold exposure include increased production of PGC1-alpha, a protein that promotes mitochondrial biogenesis, the production of new, healthy mitochondria, and the activation of brown fat – a phenomenon once thought to occur only in newborns, but now known to occur in adults, especially after cold exposure.”

“However, the term "fasting" can comprise a variety of subtypes. Intermittent fasting, a term lacking specificity, usually refers to interventions such as alternate-day fasting, fasting one day per week, or a five:two eating pattern (fasting for two days per week).”

“A perplexing aspect of SARS-CoV-2, the novel coronavirus that causes COVID-19, is that people respond to it in disparate ways — some exhibiting no symptoms at all, and others experiencing life-threatening complications.”

“A recent meta-analysis also found small benefits in selected cognitive domains, including memory and processing speed, with responses that may depend on age, diet, baseline stores, stress, dose, and the cognitive test used.”

“Acute stress may create a different context. In a double-blind crossover study of 15 adults undergoing 21 hours of sleep deprivation, a single 0.35-gram-per-kilogram dose changed brain high-energy phosphate measures and improved selected cognitive outcomes.”