Related Episodes for Psychedelic drugs, psilocybin, and transcendent experiences as antidepressants | Charles Raison

“Genetics plays an important role in longevity, but there is also a strong lifestyle component. Dr. Snyder's research, using deep molecular measurements, indicates that when you exercise, a profound molecular change occurs — particularly when it comes to immune molecules.”

“The end result is an upside-down sleep schedule in which circadian rhythms and gene expression in the body become desynchronized. In this clip, Dr. Satchin Panda describes the effects of inappropriate light signals and discusses strategies to mitigate their effects.”

“Studies of centenarians suggest that lower levels of inflammation are associated with longevity. Different types of fiber provide fuel to diverse species of bacteria in the gut, which then synthesize byproducts that regulate the inflammatory process.”

“In this clip, Drs. Levine and Patrick discuss genetic and environmental factors that can accelerate or slow epigenetic aging. Dr. Levine also discusses the aging clock she created and how it can be used, along with other biomarkers, to determine an individual's rate of aging.”

“Evidence continues to emerge that illustrates that the fasting-mimicking diet, particularly its ability to cause immune cell turnover, may provide beneficial effects in the treatment of auto-immune diseases such as multiple sclerosis.”

“In a clinical trial, researchers subjected people to three cycles of a fasting-mimicking diet and measured biomarkers including cholesterol, triglycerides, fasting glucose, IGF-1, blood pressure, and C-reactive protein.”

“A commonly observed behavior among mammals is the so-called "sickness behavior," where a person or animal that is sick will retreat, avoiding food and contact. This abstention from food induces autophagy and may serve as a means to modulate the body's inflammatory response.”

“For people seeking better-supported ways to improve inflammatory health, she points to regular exercise, marine omega-3 intake, and sulforaphane-rich foods as practical areas with a larger human evidence base.”

“Fiber plays a pivotal role in fueling good bacteria in the gut, which produce compounds that keep the immune system in check and prevent autoimmune responses. Research suggests that maintaining a protective mucin layer in the gut helps restrict the release of endotoxin from intestinal bacteria, a major source of inflammation.”

“Visceral fat can respond to changes in energy balance and physical activity. A meta-analysis of 40 randomized trials and 2,190 adults with overweight or obesity found that both exercise and calorie restriction reduced CT- or MRI-measured visceral fat.”