Related Episodes for Restricting feeding in mice to an 8-9 hour window improved endurance | Satchin Panda

“Lunch varied among sardines, mackerel, wild salmon, avocado, nuts, fruit, cheese, and quinoa salad, giving her flexible sources of protein, marine fats, fiber, and fermented foods. Dinner typically paired fish, chicken, or occasional beef with vegetables or salad.”

Dr. Eric M. Verdin discusses the roles of the ketogenic diet, beta-hydroxybutyrate, HDAC inhibitors, NAD+, and more in the context of aging.

“The physical activity guidelines and estimates on how much activity we need are heavily based on self-reported activity, which is useful but imperfect: people remember going for a run, but they forget the short, intense bursts in daily life like sprinting up stairs, chasing kids, and running to catch a bus.”

“Controlled human studies support acute brain-related responses to high-intensity exercise. Six short all-out cycling intervals improved selected learning and executive measures while increasing circulating BDNF, IGF-1, and VEGF; lactate tracked several of these changes.”

“A commonly observed behavior among mammals is the so-called "sickness behavior," where a person or animal that is sick will retreat, avoiding food and contact. This abstention from food induces autophagy and may serve as a means to modulate the body's inflammatory response.”

“Timing matters when cold exposure follows resistance training. In a 12-week study of 21 men, ten minutes of cold-water immersion immediately after each session attenuated gains in strength and muscle mass and reduced selected anabolic signals.”

“Addressing the widespread issue of physical inactivity requires exploring strategies to encourage more people to engage in various forms of physical activity, including brief and intermittent activities.”

“When produced during exercise (especially high intensity workouts like cycling, which shifts metabolism toward glycolysis to more quickly meet the high energetic demands), lactate switches on more than 600 genes involved in muscle adaptation, stimulates mitochondrial biogenesis – the process of making new mitochondria – and promotes protein synthesis, which is essential for muscle growth.”

“Dr. Patrick discusses paraquat and rotenone because both can damage mitochondria and are used experimentally to model Parkinson-like neurodegeneration, but that rationale does not prove that either chemical caused disease in this population.”

“A systematic review found no overall improvement in mood after cold-water immersion, while a small randomized trial found that repeated whole-body cryotherapy improved depression scores when added to standard pharmacological treatment.”