Related Episodes for Resveratrol and NAD boosters lead to positive impact on Alzheimer's disease & vascular dementia | David Sinclair

“There is so much to say when we talk about the NRF2 pathway and isothiocyanates like sulforaphane that we had to pack it into 47 minutes and break it into a few key sections. Key sections: For a more in-depth breakdown click the timeline link at the top of this page!”

“A meta-analysis in older adults found greater gains in lean mass and strength when creatine accompanied training, while a systematic review found the most consistent benefits after at least 12 weeks of combined use. Dr. Phillips also highlights emerging cognitive evidence.”

“In this video, Dr. Rhonda Patrick interviews Dr. Terry Wahls about how she reversed her secondary-progressive multiple sclerosis with a micronutrient-dense diet and Paleo principles.”

“A national survey analysis estimated 2.6% severe deficiency, 22% moderate deficiency, and 40.9% insufficiency among US adults, although prevalence changes with the threshold used. These categories should remain distinct because insufficiency is not the same as clinical deficiency.”

“A 12-month randomized controlled trial found that vitamin D supplementation improved cognitive function, intelligence quotient scores, telomere length, and lowered oxidative stress markers in older adults with mild cognitive impairment (compared to placebo), suggesting that not only does vitamin D supplementation improve biomarkers of aging, but also functional outcomes.”

“The SCN, in turn, coordinates the body's peripheral clocks, such as those found in the liver, pancreas, muscles, and fatty tissue, driving rhythms of rest and activity that determine eating-fasting cycles.”

“Pooled intervention data suggest that about 1.5 to 2 grams of combined EPA and DHA per day can raise the Omega-3 Index in many adults over several months, although individual responses vary.”

“Peak plasma flavan-3-ol metabolites after the banana smoothie were 84 percent lower than after the capsule, while the low-PPO berry smoothie produced levels similar to the capsule. PPO is released when plant tissue is cut, bruised, or blended and can react with selected polyphenols before they reach circulation.”

“Longer endurance aerobic exercise seems to be most effective at producing higher levels of FGF21, coinciding with anecdotes you might have heard from runners who have successfully used exercise in this sort of way. Relevant publications Flippo, Kyle H., et al.”

“A separate cohort of 12,388 adults associated vitamin D exposure with 40 percent lower dementia incidence, and a 12-month randomized trial of 183 older adults with mild cognitive impairment found improvements on several cognitive tests with 800 IU per day.”