Related Episodes for How Symptoms and Delivery Methods Shape Testosterone Therapy

“Time-restricted eating can help some people reduce eating opportunities, although a 12-month trial found no additional weight or body-fat benefit when an eight-hour eating window was added to calorie restriction. Sleep also affects appetite and fat distribution.”

“Whereas fasting turns off multiple pathways associated with aging, such as mTOR and IGF-1, eating for optimal fitness activates these important processes. The IGF-1 pathway, in particular, plays key roles in growth and is strongly associated with cancer.”

“Cholesterol-lowering drugs can act at several points in the body's handling of lipoproteins. Dr. Rhonda Patrick compares PCSK9 inhibitors, bempedoic acid, and ezetimibe, focusing on how they reduce circulating LDL and apoB-containing particles.”

“Dr. Rhonda Patrick discusses how conditioning the body to heat stress through sauna use, called "hyperthermic conditioning" may cause adaptations that increase athletic endurance (by increasing plasma volume and blood flow to heart and muscles) and potentially even muscle mass. She also discusses the profound effects of hyperthermic conditioning on the brain including cognitive function.”

“A growing body of scientific evidence suggests that there is a correlation between decreased activation of the IGF-1 pathway and increased lifespan. Studies in worms and mice indicate that when the IGF-1 receptor is knocked out, the organisms remain disease-free and live longer.”

“Bruce argues that while diseases of severe vitamin D deficiency like rickets are rare, the criteria for vitamin D deficiency should be based on long-term health biomarkers and not just short-term severe diseases.”

“Eating late at night – particularly large meals – can be detrimental and, along with DNA damage, provides fertile ground for cancer to develop. In this clip, Dr. Ruth Patterson discusses how eating in accordance with the body's natural circadian rhythm may reduce the risk of breast cancer.”

“While omega-3 is more well-known for generally promoting cancer protection, the 2008 SELECT trial seemed to show something alarming: an association between vitamin E, omega-3, and selenium supplementation and prostate cancer.”

“In STEP 1, once-weekly semaglutide plus lifestyle support produced an average weight reduction of 14.9% over 68 weeks, compared with 2.4% with placebo, establishing strong efficacy for selected adults with overweight or obesity.”

“Dr. Patrick also discusses STEP 5, in which two years of treatment produced about 15.2 percent loss versus 2.6 percent with placebo, with the curve leveling while participants remained on treatment. Dual GIP/GLP-1 therapy can produce still larger losses in some trials.”