The longevity advantage of genetic deficiencies in growth hormone/IGF-1 signaling | Valter Longo

Parent Episode: Valter Longo, Ph.D. on the Fasting-Mimicking Diet & Fasting for Longevity, Cancer & Multiple Sclerosis

A growing body of scientific evidence suggests that there is a correlation between decreased activation of the IGF-1 pathway and increased lifespan. Studies in worms and mice indicate that when the IGF-1 receptor is knocked out, the organisms remain disease-free and live longer. In humans, a naturally occurring IGF-1 deficient population exists in a region of Ecuador. These individuals live slightly longer and do not succumb to the diseases of aging compared to their relatives with typical IGF-1 receptors, regardless of diet and lifestyle practices. In this clip, Dr. Valter Longo discusses the longevity-conferring effects of diminishing the pro-aging IGF-1 pathway.

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